Adenosine receptor antagonist compounds

A compound of formula (Ib)

• wherein:
• R is H, (C1-C3)alkyl, or substituted (C1-C3)alkyl;
• Y1 to Y4 are independently selected from CR10;
• each R10 is independently selected from H, (C1-C8)alkyl, substituted (C1-C8)alkyl, (C2-C8)alkenyl, substituted (C2-C8)alkenyl, (C2-C8)alkynyl, substituted (C2-C8)alkynyl, (C1-C3)haloalkyl, (C1-C8)alkoxy, substituted (C1-C8)alkoxy, —CONH2, substituted amido, —NH2, substituted amino, —CO2H, halogen, hydroxyl, —NO2, —SO3H, —SO2NH2, substituted sulfonamide, and thiol, with proviso that Y1 is not CH;
• Ra and Rb are each independently selected from H, F, (C1-C3)alkyl, and substituted (C1-C3)alkyl;
• and
• A is phenyl or phenyl substituted with one, two or three R20 groups, each R20 is independently selected from (C1-C8)alkyl, substituted (C1-C8)alkyl, (C2-C8)alkenyl, substituted (C2-C8)alkenyl, (C2-C8)alkynyl, substituted (C2-C8)alkynyl, (C1-C3)haloalkyl, (C1-C8)alkoxy, substituted (C1-C8)alkoxy, —CONH2, substituted amido, —NH2, substituted amino, —CO2H, cyano, halogen, hydroxyl, —NO2, —SO3H, —SO2NH2, substituted sulfonamide, and thiol;
• wherein one or more substituents of substituted (C1-C3)alkyl, substituted (C1-C8)alkyl, substituted (C2-C8)alkenyl, substituted (C2-C8)alkynyl, substituted (C1-C8)alkoxy, substituted amido, substituted amino, and substituted sulfonamide are independently selected from halogen, hydroxy, oxo (═O), thioxo (═S), cyano (—CN), nitro (—NO2), imino (═N—H), oximo (═N—OH), —CONH2, —NH2, —CO2H, —SO3H, —SO2NH2, thiol and hydrazino (═N—NH2),
• or a solvate, a hydrate, and/or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.