Substituted indoles with inhibitory activity

A compound having a structure according to Formula I-A-9:

• wherein
• L1 is a linker selected from a bond, —C1-C6 alkylene-, —C1-C6 alkoxy-, and —C1-C6 alkylamide-, and wherein L1 is optionally substituted with one or more groups;
• L2 is a linker selected from a bond, and —C1-C6 alkylene-, and wherein L2 is optionally substituted with one or more groups;
• R1 is selected from hydrogen, and C1-C6 alkyl, wherein R1 is optionally substituted or unsubstituted;
• R2 is selected from aryl, and heteroaryl, wherein R2 is substituted with one or more groups selected from alkyl, haloalkyl, alkoxy, haloalkoxy, amine, alkylamine, amide, alkylamide, hydroxyl, cycloalkyl, heterocycloalkyl, cyano, nitro, ester, and —SF5;
• R3 is selected from wherein R″, and R′″ are independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, substituted or unsubstituted cycloalkyl, or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkenyl, heterocycloalkyl, cycloheteroalkenyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is selected from hydrogen, halogen, alkyl, haloalkyl, and heteroalkyl, and wherein R4 is optionally substituted with one or more groups;
• and
• R5 is selected from hydrogen, and C1-C6 alkyl;
• or a pharmaceutically acceptable salt, ester, or prodrug thereof.