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US 12,606,549 B2Granted
Anticholinergic agents
AssigneeRezubio Pharmaceuticals Co., Ltd
InventorsYusheng Xiong, Hongping Guan
Life of this patent
Estimating the term…
Abstract
Compounds shown in Formula (I), pharmaceutical compositions, and methods of using related to muscarinic acetylcholine receptors. The compounds herein are typically muscarinic acetylcholine receptor antagonists, such as M3 antagonists, which can be used for treating a variety of disorders, conditions or diseases such as hyperhidrosis.
Claims19
A salt having Formula I:
- wherein:
- X− is a counterion;
- R1 is hydrogen;
- L1 is null, C1-4 alkylene, or C1-4 heteroalkylene;
- R2 is C3-8 carbocyclyl, 4-8 membered heterocyclyl, phenyl, or 5-10 membered heteroaryl, each of which is optionally substituted;
- R3 and R4 are each independently hydrogen or C1-6 alkyl;
- and
- j is 0, 1 or 2.
5 more elements
A salt selected from those shown in Table 1 or 2, wherein X− is a pharmaceutically acceptable counterion:
- TABLE 1
- TABLE 2
A compound having Formula II, or a salt thereof:
- wherein:
- R1 is hydrogen;
- L1 is null, C1-4 alkylene, or C1-4 heteroalkylene;
- R2 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 carbocyclyl, 4-8 membered heterocyclyl, phenyl, or 5-10 membered heteroaryl, each of which is optionally substituted;
- R3 is hydrogen or C1-6 alkyl;
- and
- j is 0, 1 or 2.
4 more elements
Dependencies are inferred from the claim text.