US 12,606,541 B2Granted

PPARg modulators and methods of use

AssigneeEisai R&D Management Co., Ltd.

InventorsSudeep Prajapati, Hyelee Lee, Stephanos Ioannidis, Kiyoyuki Omoto, Alan Rolfe, Xiang Liu, Megan Carty, Paul Dransfield, Andrew Cook

Life of this patent

Estimating the term…

Abstract

Disclosed herein are novel compounds of Formula (1) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, and methods of using the same.

Claims34

Dependent claims

A compound of Formula (I)

or a pharmaceutically acceptable salt thereof,
wherein:
Ar1 is chosen from
wherein
Y1 is chosen from N and C—X1 wherein X1 is chosen from hydrogen, hydroxyl, halogen, and C1-C4 alkyl;
R3 is chosen from hydrogen, optionally substituted alkyl, optionally substituted amine, halogen, cyano, and optionally substituted alkoxy;
and
R4 is chosen from hydrogen and optionally substituted alkyl;
either Y2 is chosen from C—X2 and N and Y3 is NH, or
Y2 is N and Y3 is C(X2)2,
wherein each X2 is independently chosen from hydrogen and halogen;
Ring A is chosen from
wherein q is 0 or 1;
R1 is chosen from —(CHR5)k—(CR6R7)n—(O)m-Ring B, wherein
k is 0 or 1,
n is 0 or 1,
m is 0 or 1,
R5 is chosen from hydrogen and optionally substituted alkyl,
R6 is chosen from hydrogen and halogen,
R7 chosen from hydrogen and halogen, and
Ring B is chosen from
optionally substituted aryl,
optionally substituted heteroaryl,
optionally substituted cycloalkyl,
optionally substituted heterocycloalkyl,
optionally substituted cycloalkenyl, and
optionally substituted heterocycloalkenyl;
and
R2 is chosen from hydrogen and optionally substituted alkyl.

26 more elements

At least one compound chosen from:

1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4s)-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(4-fluoro-5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-methylcyclohexyl)piperidine-4-carboxamide;
(S)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(3-fluorophenyl)ethyl)piperidine-4-carboxamide;
N-((1s,4s)-4-(difluoromethyl)cyclohexyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1r,4r)-4-(difluoromethyl)cyclohexyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-methylcyclohexyl)piperidine-4-carboxamide;
N-(4-methylcyclohexyl)-1-[5-(2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]piperidine-4-carboxamide;
1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4s)-4-methylcyclohexyl)piperidine-4-carboxamide;
N-((1s,4s)-4-ethylcyclohexyl)-1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1r,4r)-4-ethylcyclohexyl)-1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(3-chloropyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-methylcyclohexyl)piperidine-4-carboxamide;
1-[4-chloro-5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-methylcyclohexyl]piperidine-4-carboxamide;
1-[4-chloro-5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-methylcyclohexyl]piperidine-4-carboxamide;
1-[5-(6-methoxypyrimidin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-methylcyclohexyl]piperidine-4-carboxamide;
1-[5-(6-methoxypyrimidin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-methylcyclohexyl]piperidine-4-carboxamide;
1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(3-chlorophenyl)methyl]piperidine-4-carboxamide;
N-((1s,4s)-4-(difluoromethyl)cyclohexyl)-1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1r,4r)-4-(difluoromethyl)cyclohexyl)-1-(5-(2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4s)-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-methylcyclohexyl)piperidine-4-carboxamide;
(R)-1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[1-(3-chlorophenyl)ethyl]piperidine-4-carboxamide;
(S)-1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[1-(3-chlorophenyl)ethyl]piperidine-4-carboxamide;
1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-(1-phenylpyrrolidin-3-yl)piperidine-4-carboxamide;
1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-(trifluoromethyl)cyclohexyl]piperidine-4-carboxamide;
1-[5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-(trifluoromethyl)cyclohexyl]piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(imidazo[1,2-a]pyridin-2-ylmethyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-chloropyridin-2-yl)methyl)piperidine-4-carboxamide;
1-[5-(5-Chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-(2-methyl-1,3-dioxan-5-yl) piperidine-4-carboxamide;
N-((1H-indol-5-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2,3,6-trifluorobenzyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-chloro-5-fluorobenzyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoropyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-cyanocyclobutyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-methylpyridin-3-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(isochroman-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,2S)-2-phenylcyclopropyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-hydroxycyclohexyl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4,4-dimethyloxetan-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-methyloxazol-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(pyrazolo[1,5-a]pyridin-7-ylmethyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-chloropyrimidin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-chloropyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1,5-dimethyl-1H-pyrazol-3-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(4-chlorophenoxy)propan-2-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3,3-difluorocyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-methoxycyclobutyl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-fluoropyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-(difluoromethyl)phenyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3,3-difluorocyclobutyl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2,2-difluoro-2-phenylethyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3,3,5-trimethylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-(difluoromethoxy)benzyl)piperidine-4-carboxamide;
N-(benzo[d]oxazol-6-ylmethyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
(R)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(3-fluorophenyl)ethyl)piperidine-4-carboxamide;
N-(5-chloro-2-fluorobenzyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2,3-difluorobenzyl)piperidine-4-carboxamide;
N-(3-chloro-2-fluorobenzyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-fluorobenzyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3,4-dihydro-2H-pyran-2-yl)methyl)piperidine-4-carboxamide;
N-(3-chlorobenzyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
(1R,3s,5S)—N-(3-chlorobenzyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3r,5S)—N-(3-chlorobenzyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
N-(3-chlorobenzyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-methylpiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(trifluoromethyl)cyclopentyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1,4-dimethylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-(trifluoromethoxy)benzyl)piperidine-4-carboxamide;
N-(bicyclo[3.2.1]octan-8-yl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-[(3-chlorophenyl)methyl]-1-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-1,2,4-triazole-3-carbonyl]piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-oxoindolin-5-yl)methyl)piperidine-4-carboxamide;
N-((1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-4-hydroxypiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2-methylpiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-3-methylpiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-4-fluoropiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3,3-difluorocyclopentyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methylpyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-3-fluoropiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6-(trifluoro-15-methyl)pyridin-3-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-chloropyridin-3-yl)methyl)piperidine-4-carboxamide;
N-((1H-indazol-6-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1H-indol-3-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(isoquinolin-6-ylmethyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(chroman-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-methyl-1,2,3,4-tetrahydroquinolin-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-indol-3-yl)methyl)piperidine-4-carboxamide;
N-((1H-indol-6-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methylfuran-2-yl)methyl)piperidine-4-carboxamide;
N-((1H-indol-4-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5,6,7,8-tetrahydroisoquinolin-5-yl)piperidine-4-carboxamide;
N-((1H-indazol-4-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxamide;
N-((1H-indol-7-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-fluorochroman-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-phenylpiperidin-4-yl)piperidine-4-carboxamide;
N-((2H-benzo[d][1,2,3]triazol-5-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
N-((3-fluoro-1H-indazol-5-yl)methyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1H-indazol-3-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
N-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-methyl-1H-indol-5-yl)methyl)piperidine-4-carboxamide;
1-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(3-methyl-1H-indazol-5-yl)methyl]piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-isopropyl-1H-pyrazol-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-indol-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-oxo-1-phenylpyrrolidin-3-yl)piperidine-4-carboxamide;
N-(5-chloro-2,3-dihydrobenzofuran-3-yl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-(trifluoromethyl)pyrimidin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methylimidazo[1,2-a]pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(trifluoromethyl)pyrimidin-2-yl)methyl)piperidine-4-carboxamide;
N-((1H-pyrrolo[2,3-c]pyridin-5-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5,5-dimethyltetrahydrofuran-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((8-fluoroimidazo[1,2-a]pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-methyl-1H-benzo[d]imidazol-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-methyl-1,3-dioxan-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6-methylimidazo[1,2-a]pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-indazol-3-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6-chloroimidazo[1,2-a]pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4,4-difluorotetrahydrofuran-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(trifluoromethyl)oxazol-4-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(2-fluorophenyl)pyrrolidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-benzo[d]imidazol-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-methyl-5,6,7,8-tetrahydroquinazolin-5-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(difluoromethyl)isoxazol-3-yl)methyl)piperidine-4-carboxamide;
N-((1H-pyrrolo[2,3-b]pyridin-6-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-indazol-6-yl)methyl)piperidine-4-carboxamide;
N-((2-oxabicyclo[3.1.1]heptan-1-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-methyl-2,2-dioxido-3,4-dihydro-1H-benzo[c][1,2]thiazin-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)piperidine-4-carboxamide;
(S)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-cyanochroman-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinolin-5-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-2-oxoindolin-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-(difluoromethyl)pyrimidin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6-(difluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3,3-dimethyl-2-oxoindolin-5-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoro-1H-benzo[d]imidazol-4-yl)methyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)piperidine-4-carboxamide;
(S)-4-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-4-azaspiro[2.5]octane-7-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-fluoro-3-methylcyclobutyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5-methyltetrahydrofuran-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)piperidine-4-carboxamide;
N-((1H-indol-2-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-methylpyridin-2-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-methoxychroman-4-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(4-fluorophenyl)pyrrolidin-3-yl)piperidine-4-carboxamide;
N-((1H-pyrrolo[3,2-c]pyridin-4-yl)methyl)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
(S)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,2-dimethylpiperidine-4-carboxamide;
(R)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,2-dimethylpiperidine-4-carboxamide;
(S)-5-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-5-azaspiro[3.5]nonane-8-carboxamide;
(R)-5-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-5-azaspiro[3.5]nonane-8-carboxamide;
(1R,3s,5S)-8-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)—N-[(3-fluoro-1H-indazol-5-yl)methyl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5,6-dimethylpyrazin-2-yl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1H-indol-4-yl)piperidine-4-carboxamide;
1-[5-(5-chloro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(3-chlorophenyl)methyl]piperidine-4-carboxamide;
1-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl]piperidine-4-carboxamide;
1-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-hydroxy-4-(trifluoromethyl)cyclohexyl]piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4s)-4-hydroxy-4-methylcyclohexyl)piperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-methyl-2,3-dihydrobenzofuran-3-yl)piperidine-4-carboxamide;
(2S,5R)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,5-dimethylpiperidine-4-carboxamide;
(2R,5S)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,5-dimethylpiperidine-4-carboxamide;
(2R,5R)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,5-dimethylpiperidine-4-carboxamide;
(2S,5S)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,5-dimethylpiperidine-4-carboxamide;
N-[(3-chlorophenyl)methyl]-1-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]piperidine-4-carboxamide;
(1R,3S,5S)—N-[(3-chlorophenyl)methyl]-8-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
N-[(3-fluoro-1H-indazol-5-yl)methyl]-1-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]piperidine-4-carboxamide;
1-[5-(5-chloro-2-ethylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(3-chlorophenyl)methyl]piperidine-4-carboxamide;
1-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-(1H-indol-5-ylmethyl)piperidine-4-carboxamide;
N-[(2,3-dimethyl-1H-indol-5-yl)methyl]-1-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]piperidine-4-carboxamide;
(2R,4R)-1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2-methylpiperidine-4-carboxamide;
1-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-chlorobenzyl)-2,6-dimethylpiperidine-4-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-oxaspiro[3.5]nonan-7-yl)piperidine-4-carboxamide;
(1R,3s,5S)—N-((3-fluoro-1-methyl-1H-indazol-5-yl)methyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
N-((3,3-dimethylindolin-5-yl)methyl)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxamide;
(1R,3s,5S)—N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(3-methyl-1H-indazol-5-yl)ethyl)piperidine-4-carboxamide;
9-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-3-oxa-9-azabicyclo[3.3.1]nonane-7-carboxamide;
(1R,3R,5S)-8-[5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-((3-fluoro-1H-indazol-5-yl)methyl)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3R,5S)—N-[(2,3-dimethyl-1H-indol-5-yl)methyl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)-4-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-chloro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-fluoro-1H-indazol-5-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-fluoro-1H-indazol-5-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-6-(trifluoromethyl)tetrahydro-2H-pyran-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)ethyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)ethyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-(1,1-dimethylsilinan-4-yl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3R,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-methoxy-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3R,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-methoxy-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5R,8r)-2-oxo-1-azaspiro[4.5]decan-8-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5S,8s)-2-oxo-1-azaspiro[4.5]decan-8-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
4-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N—[(R)-1-(2-fluorophenyl)pyrrolidin-3-yl]-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3S,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[1-oxaspiro[3.5]nonan-7-yl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(2R,4S,5S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2S,4S,5S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2R,4R,5S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2R,4S,5R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2S,4S,5R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2S,4R,5S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2R,4R,5R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(2S,4R,5R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,5-dimethylpiperidine-4-carboxamide;
(1R,3S,5S)—N-[(3S,6S)-1-ethyl-6-(trifluoromethyl)piperidin-3-yl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)—N-[(3S,6R)-1-ethyl-6-(trifluoromethyl)piperidin-3-yl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)—N-[(3R,6S)-1-ethyl-6-(trifluoromethyl)piperidin-3-yl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)—N-[(3S,6R)-1-ethyl-6-(trifluoromethyl)piperidin-3-yl]-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-oxaspiro[3.5]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-oxaspiro[3.5]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(4-hydroxy-4-(perfluoroethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3R,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-(difluoromethyl)-4-methoxycyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3R,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-(difluoromethyl)-4-methoxycyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-((1r,4R)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-((1s,4S)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1r,4r)-4-(2-methoxyethoxy)-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl]-N-[(1s,4s)-4-(2-methoxyethoxy)-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3S,5S)-8-[5-(5-fluoro-2-methoxypyridin-4-yl)-1H-1,2,4-triazole-3-carbonyl]-N-[(1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl]-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-(3,3-difluoro-1-oxaspiro[3.5]nonan-7-yl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(S)—N-((1r,4S)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,4R)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1r,4R)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1s,4S)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1s,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
4-(4-(5-hydroxy-2-methylpyridin-4-yl)-1H-imidazole-2-carbonyl)-N-((1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)—N-((1r,4S)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4R)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.2.2]octan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.2.2]octan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(2,3-dimethylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-(5-(6-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(2-ethylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-8-(5-(2-(hydroxymethyl)pyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-(trifluoromethyl)-1-oxaspiro[3.5]nonan-7-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-(3,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-(4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-methyl-6-(trifluoromethyl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1r,4R)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-ethoxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-methoxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4S,7r)-1-oxaspiro[3.5]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4R,7s)-1-oxaspiro[3.5]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6S)-1-(2-fluoro-2-methylpropyl)-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6S)-1-(2-fluoro-2-methylpropyl)-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,6R)-1-(2-fluoro-2-methylpropyl)-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,6R)-1-(2-fluoro-2-methylpropyl)-6-(trifluoromethyl)piperidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5R,8r)-1-methyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5S,8s)-1-methyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5S,8r)-1-methyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5R,8s)-1-methyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5R,8r)-1-ethyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5S,8s)-1-ethyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5S,8r)-1-ethyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5R,8s)-1-ethyl-2-oxo-1-azaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-(2-(dimethylamino)ethoxy)-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-(2-hydroxyethoxy)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-(2-hydroxyethoxy)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.2.1]heptan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.2.1]heptan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.1.1]hexan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-hydroxybicyclo[2.1.1]hexan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-hydroxybicyclo[1.1.1]pentan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((2-oxabicyclo[2.1.1]hexan-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((2-oxabicyclo[2.1.1]hexan-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methoxypyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methoxypyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(6-methylpyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1 S,4S)-4-((S)-2-methoxypropoxy)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,4S)-4-((R)-2-methoxypropoxy)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((R)-4,5,6,7-tetrahydro-2H-indazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((S)-4,5,6,7-tetrahydro-2H-indazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-7-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-7-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—((R)-1-(2-hydroxy-2-methylpropyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—((R)-1-(2-hydroxy-2-methylpropyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—((S)-1-(2-hydroxy-2-methylpropyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—((S)-1-(2-hydroxy-2-methylpropyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((R)-3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N—(((S)-3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1r,4R)—N—((R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octan-7-yl)-4-hydroxy-4-(trifluoromethyl)cyclohexane-1-carboxamide;
(1s,4S)—N—((R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octan-7-yl)-4-hydroxy-4-(trifluoromethyl)cyclohexane-1-carboxamide;
(1r,4S)—N—((S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octan-7-yl)-4-hydroxy-4-(trifluoromethyl)cyclohexane-1-carboxamide;
(1s,4R)—N—((S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octan-7-yl)-4-hydroxy-4-(trifluoromethyl)cyclohexane-1-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(oxetan-3-yl)-1-azaspiro[4.5]decan-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-(2-aminoethoxy)-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(1-(2,2-difluoropropyl)-1-azaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,4S)-4-((S)-2-aminopropoxy)-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1 S,4S)-4-((S)-2-hydroxypropoxy)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-(8-oxabicyclo[3.2.1]octan-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,3R)-3-(3,3-difluoropyrrolidin-1-yl)-2,2-dimethylcyclobutyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,3S)-3-(3,3-difluoropyrrolidin-1-yl)-2,2-dimethylcyclobutyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((S)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((R)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((S)-3-(trifluoromethyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-6-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((R)-3-(trifluoromethyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-6-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-methylpyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(3-chloropyridin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(3-chloropyridin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoro-3-methylpyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoro-3-(trifluoromethyl)pyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(2S,4R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(trifluoromethyl)piperidine-4-carboxamide;
(2S,4S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(trifluoromethyl)piperidine-4-carboxamide;
(2R,4R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(trifluoromethyl)piperidine-4-carboxamide;
(2R,4S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(trifluoromethyl)piperidine-4-carboxamide;
(R)—N-((1r,4R)-4-(1,1-difluoro-2-methoxyethyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((1s,4S)-4-(1,1-difluoro-2-methoxyethyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5S,8s)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5R,8r)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(((1R,3S)-1-imino-2,2-dimethyl-1-oxidotetrahydro-1H-116-thiophen-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(((1 S,3S)-1-imino-2,2-dimethyl-1-oxidotetrahydro-1H-116-thiophen-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(((1 S,3R)-1-imino-2,2-dimethyl-1-oxidotetrahydro-1H-116-thiophen-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(((1R,3R)-1-imino-2,2-dimethyl-1-oxidotetrahydro-1H-116-thiophen-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(perfluoroethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4R)-4-hydroxy-4-(perfluoroethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((4S,7r)-3,3-difluoro-1-oxaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((4R,7s)-3,3-difluoro-1-oxaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,4R)-4-(1,1-difluoroethyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-(1,1-difluoroethyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6R,8aR)-octahydroindolizin-6-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6R,8aS)-octahydroindolizin-6-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6S,8aR)-octahydroindolizin-6-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((6S,8aS)-octahydroindolizin-6-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(3-chloro-5-fluoropyridin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(3-chloro-5-fluoropyridin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,3R)-3-(3,3-difluoropyrrolidin-1-yl)-2,2,4,4-tetramethylcyclobutyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,3S)-3-(3,3-difluoropyrrolidin-1-yl)-2,2,4,4-tetramethylcyclobutyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-4,4-difluoro-1-(2-fluoro-2-methylpropyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-4,4-difluoro-1-(2-fluoro-2-methylpropyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-6-methyl-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-6-methyl-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5-methylpyrazolo[1,5-a]pyrimidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((S)-3-methyl-4,5,6,7-tetrahydro-1H-indazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—(((R)-3-methyl-4,5,6,7-tetrahydro-1H-indazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-7-fluoro-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-7-fluoro-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(R)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-methylpyridazin-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-chloro-2-methylpyrimidin-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloropyrazin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoro-3-methoxypyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(pyridin-3-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(pyridin-3-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-cyanopyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-(oxetan-3-yl)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-(3-cyanoazetidin-1-yl)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-methyl-5-(trifluoromethyl)oxazol-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-methylpyrazin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-(1,1-difluoro-3-methoxypropyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,4R)-4-(1,1-difluoro-3-methoxypropyl)-4-hydroxycyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1s,4R)-4-amino-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-amino-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3,5-difluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(2S,4S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-methylpiperidine-4-carboxamide;
(2R,4S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-methylpiperidine-4-carboxamide;
(2R,4R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-methylpiperidine-4-carboxamide;
(2S,4R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-methylpiperidine-4-carboxamide;
(S)—N-((3-chloro-5-methoxypyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(2R,4S)-2-ethyl-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
(2S,4R)-2-ethyl-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
(2S,4S)-2-ethyl-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
(2R,4R)-2-ethyl-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)piperidine-4-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-fluoro-3-(4-methylpiperazin-1-yl)pyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5R,8r)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5S,8s)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5S,8r)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5R,8s)-4,4-difluoro-1-oxaspiro[4.5]decan-8-yl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-((1-fluorocyclopropyl)methyl)azetidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,2-dimethylpiperidine-4-carboxamide;
(R)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2,2-dimethylpiperidine-4-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4R)-4-(hydroxymethyl)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-(hydroxymethyl)-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-(1-(tert-butylsulfinyl)-3,3-difluoro-1-azaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((4S,7r)-3,3-difluoro-1-azaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((4R,7s)-3,3-difluoro-1-azaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(4-hydroxybicyclo[2.2.2]octan-1-yl)ethyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(4-hydroxybicyclo[2.2.2]octan-1-yl)ethyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((4,6-dimethylpyridazin-3-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((5-chloropyrimidin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3S,4R)-4-morpholinotetrahydrofuran-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3R,4S)-4-morpholinotetrahydrofuran-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)ethyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(pyrazolo[1,5-a]pyridin-7-ylmethyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(oxetan-3-yl)piperidin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-morpholinocyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1s,4R)-4-morpholinocyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,5S,7r)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,5S,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(methylsulfonyl)piperidin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(oxetan-3-yl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(oxetan-3-yl)piperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3R,4S)-4-fluoro-1-methylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,4S)-4-fluoro-1-methylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3R,4R)-4-fluoro-1-methylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,4R)-4-fluoro-1-methylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,6S)-1,6-dimethylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3R,6R)-1,6-dimethylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,6R)-1,6-dimethylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3R,6S)-1,6-dimethylpiperidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1,6,6-trimethylpiperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1,6,6-trimethylpiperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(2-fluoroethyl)-2,2-dimethylpiperidin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(2-fluoroethyl)-2,2-dimethylpiperidin-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3R,4R)-4-fluoro-1-(6-methylpyridin-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,4S)-4-fluoro-1-(6-methylpyridin-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3S,4R)-4-fluoro-1-(6-methylpyridin-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(2-methylpyrimidin-4-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(2-methylpyrimidin-4-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-(trifluoromethyl)pyrazin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-((S)-tetrahydrofuran-3-yl)azetidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-((R)-tetrahydrofuran-3-yl)azetidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-((3-chloro-5-(3,5-dimethylpiperazin-1-yl)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-4,4-difluoro-1-((1-(trifluoromethyl)cyclopropyl)methyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-4,4-difluoro-1-((1-(trifluoromethyl)cyclopropyl)methyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)—N-(4-(1,1-difluoro-2-hydroxyethyl)-4-hydroxycyclohexyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-((1-(trifluoromethyl)cyclopropyl)methyl)pyrrolidin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(1R,3s,5S)—N-(4-cyano-4-(trifluoromethyl)cyclohexyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(S)—N-((1s,4R)-4-(cyanomethyl)-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1r,4S)-4-(cyanomethyl)-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((2-(2-fluoro-2-methylpropyl)-2-azabicyclo[2.1.1]hexan-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(1R,3s,5S)—N-(4-amino-4-(trifluoromethyl)cyclohexyl)-8-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octane-3-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(2-(2-fluoro-2-methylpropyl)-2-azabicyclo[2.1.1]hexan-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexan-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
5-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-oxa-5-azaspiro[3.5]nonane-8-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5-((R)-1-hydroxyethyl)pyrazolo[1,5-a]pyrimidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(5-((S)-1-hydroxyethyl)pyrazolo[1,5-a]pyrimidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-(oxetan-3-yloxy)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-((5-(3,5-dimethylpiperazin-1-yl)pyrimidin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(1-cyanocyclopropyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(2-methoxy-5-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1,6,6-trimethylpiperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1,6,6-trimethylpiperidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-6-methylpyrazin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(6-methylpyridazin-4-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(6-methylpyridazin-4-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(2-methylpyrimidin-5-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(2-methylpyrimidin-5-yl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-((3-hydroxyoxetan-3-yl)methyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-((3-hydroxyoxetan-3-yl)methyl)pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methoxypyrimidin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-cyanopyrimidin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(trifluoromethyl)pyrimidin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(1-(3,5-dichloropyridin-2-yl)cyclopropyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(2,2-difluoro-3-hydroxypropyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(2,2-difluoro-3-hydroxypropyl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,4S)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,4R)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-((R)-1-oxa-6-azaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-((S)-1-oxa-6-azaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-((R)-1-oxa-6-azaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-((S)-1-oxa-6-azaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-chloropyridin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1 S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-chloropyridin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((3-hydroxyoxetan-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-((R)-1-oxaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-((S)-1-oxaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-((R)-1-oxaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-((S)-1-oxaspiro[3.3]heptan-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1,4,5-trimethyl-1H-imidazol-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(5-((1 S,2S)-2-cyanocyclopropyl)pyrazolo[1,5-a]pyrimidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(5-((1R,2R)-2-cyanocyclopropyl)pyrazolo[1,5-a]pyrimidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyrimidin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1 S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyrimidin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-fluoropyrazolo[1,5-a]pyridin-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-fluoropyrazolo[1,5-a]pyridin-7-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1 S,6R)-2,5-diazabicyclo[4.1.0]heptan-2-yl)pyrimidin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-((1R,6S)-2,5-diazabicyclo[4.1.0]heptan-2-yl)pyrimidin-2-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-4,4-difluoro-1-((1-hydroxycyclopropyl)methyl)pyrrolidin-3-yl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-4,4-difluoro-1-((1-hydroxycyclopropyl)methyl)pyrrolidin-3-yl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(pyrrolidin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(5-cyanopyrimidin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(5-cyanopyrimidin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,3R,4S)-3,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,3S,4R)-3,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,3R,4S)-3,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,3S,4R)-3,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)ethyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)ethyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((5-(trifluoromethyl)-1H-imidazol-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
4-(5-(2-acetyl-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-((S)-1-hydroxyethyl)pyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-((S)-1-hydroxyethyl)pyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-((R)-1-hydroxyethyl)pyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(5-fluoro-2-((R)-1-hydroxyethyl)pyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(2-cyclopropyl-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(2-cyclopropyl-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-((1 S,2S)-2-(hydroxymethyl)cyclopropyl)pyrazin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((3-((1R,2R)-2-(hydroxymethyl)cyclopropyl)pyrazin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((2-((3S,5R)-3,5-dimethylpiperazin-1-yl)-5-(trifluoromethyl)oxazol-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(2-ethyl-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-chloro-5-fluoropyridin-2-yl)methyl)-4-(5-(2-ethyl-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-methoxypyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-chloro-5-methoxypyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-(trifluoromethyl)-2-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)oxazol-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-5-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-5-azaspiro[3.5]nonane-8-carboxamide;
(R)-5-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-5-azaspiro[3.5]nonane-8-carboxamide;
(S)—N-(5-cyanopyrazolo[1,5-a]pyrimidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-(1-(6-cyanopyridin-3-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-1-(5-cyanopyridin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-1-(5-cyanopyridin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((S)-4,4-difluoro-1-(5-methylpyrazin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—((R)-4,4-difluoro-1-(5-methylpyrazin-2-yl)pyrrolidin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-isopropoxypyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-3-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(5-fluoro-2-methoxy-3-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxy-3-methylpyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(6-acetylpyrazolo[1,5-a]pyridin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-((S)-1-hydroxyethyl)pyrazolo[1,5-a]pyridin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(6-((R)-1-hydroxyethyl)pyrazolo[1,5-a]pyridin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-(7′,8′-dihydro-6′H-spiro[oxetane-3,5′-quinolin]-8′-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(7S)—N-(5-ethyl-2-oxa-5-azaspiro[3.5]nonan-7-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-(5,5-dimethyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1-(aminomethyl)-2-oxabicyclo[2.1.1]hexan-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,3R,4S)-3-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1 S,3S,4R)-3-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((4-(trifluoromethyl)-1H-imidazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,2R,4S)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,2S,4S)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,2R,4S)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,2S,4S)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,2R,4R)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1 S,2S,4R)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,2R,4R)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((1R,2S,4R)-2,4-dihydroxy-4-(trifluoromethyl)cyclohexyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((3-(trifluoromethyl)isoxazol-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-cyclopropylpyridin-2-yl)methyl)-4-(3-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)—N-((3-cyclopropylpyridin-2-yl)methyl)-4-(3-(5-fluoro-2-methylpyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((1-methyl-4-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((1-methyl-5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((3-(trifluoromethyl)pyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—(((S)-3,3-difluoropiperidin-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N—(((R)-3,3-difluoropiperidin-4-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((5-fluoropyrimidin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-5-hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-5-hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((4-(trifluoromethyl)pyridin-3-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((2-methyl-4-(trifluoromethyl)thiazol-5-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((R)-1-(hydroxymethyl)-3-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N—((S)-1-(hydroxymethyl)-3-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((1-(trifluoromethyl)-1H-imidazol-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-(1-(hydroxymethyl)-2-oxabicyclo[2.1.1]hexan-4-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((3-chloro-5-(4-methylpiperazin-1-yl)pyridin-2-yl)methyl)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,3S)-3-hydroxy-3-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1 S,3S)-3-hydroxy-3-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1R,3R)-3-hydroxy-3-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1 S,3R)-3-hydroxy-3-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-N-((3-(trifluoromethyl)pyridin-4-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)—N-((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-4-(3-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-5-carbonyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methoxy-3-(trifluoromethyl)pyridin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(6-cyanopyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(6-cyanopyrimidin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(2-chloro-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4S)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(R)-4-(5-(2-chloro-5-fluoropyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((1r,4R)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-4-azaspiro[2.5]octane-7-carboxamide;
(S)-4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-((5-methoxy-3-(trifluoromethyl)pyrazin-2-yl)methyl)-4-azaspiro[2.5]octane-7-carboxamide;
and pharmaceutically acceptable salts thereof.

651 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/521,666Filed 8 Nov 2021 · us provisional application
Priority: 9 Nov 2020
Published: US 2023/0062861 A12 Mar 2023
Granted: 21 Apr 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61P 35/00
Antineoplastic agents
C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
C07D 405/14
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having…:…
C07D 409/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms: containing three…

Family

Application63/111,354Us provisional application · filed 9 Nov 2020
US 2023/0062861 A1Pre-grant publication · published 2 Mar 2023
US 12,606,541 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Disclosed herein are novel compounds of Formula (1) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, and methods of using the same.

Facts

Application

17/521,666Filed 8 Nov 2021 · us provisional application

Priority

9 Nov 2020

Published

US 2023/0062861 A12 Mar 2023

Granted

21 Apr 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61P 35/00
Antineoplastic agents
C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
C07D 405/14
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having…:…
C07D 409/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms: containing three…