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US 12,606,540 B2Granted
Triazolone compound
AssigneeMedshine Discovery Inc.
InventorsShuhui Chen, Zhengxia Chen
Life of this patent
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Abstract
The present invention discloses a series of triazolone compounds, and specifically discloses a compound and a pharmaceutically acceptable salt thereof as shown in formula (V).
Claims11
A compound represented by formula (V) or a pharmaceutically acceptable salt thereof,
- wherein,
- ring A is selected from phenyl, pyridinyl, pyrrolyl, pyrazolyl, imidazolyl and 1,2,4-triazolyl, and the phenyl, pyridinyl, pyrrolyl, pyrazolyl and imidazolyl are optionally substituted by 1, 2 or 3 Ra;
- E1 is selected from CH2 and O;
- T1 is selected from CR4 and N;
- T2 is selected from CH and N;
- T3 is selected from CR and N;
- R1 is selected from CH2OH, COOH and CONH2;
- R2 is selected from C1-3 alkyl, and the C1-3 alkyl is optionally substituted by 1, 2 or 3 Rb;
- R3 and R4 are each independently selected from H, F, Cl, CN, CH3 and OCH3, and the CH3 and OCH3 are optionally substituted by 1, 2 or 3 Rc;
- R5 is selected from H, F, Cl and CN;
- R6 is selected from H and F;
- R7 is selected from H and
- each Ra is independently selected from F and Cl;
- each Rb is independently selected from F, Cl and Br;
- each Rc is independently selected from F, Cl and Br.
12 more elements
A compound represented by the following formula or a pharmaceutically acceptable salt thereof, selected from:
Dependencies are inferred from the claim text.