Sulfur and amide tropolone inhibitors of nucleotidyl transferases and uses therefor

A compound of the formula:

• wherein:
• R1 and R2 are each independently hydrogen, alkyl(C≤8), substituted alkyl(C≤8), acyl(C≤8), or substituted acyl(C≤8);
• R3 and R4 are each independently hydrogen, halo, hydroxy, alkyl(C≤8), substituted alkyl(C≤8), aryl(C≤12), or substituted aryl(C≤12);
• R5 is hydrogen, alkyl(C≤8), substituted alkyl(C≤8), aryl(C≤12), or substituted aryl(C≤12);
• and
• R7 is an amino acid residue, heterocycloalkyl(C≤12), substituted heterocycloalkyl(C≤12), —N(R8)R9,
• wherein:
• R8 is hydrogen, alkyl(C≤8), substituted alkyl(C≤8);
• and
• R9 is alkyl(C4-8), substituted alkyl(C4-8), alkynyl(C≤12), aryl(C≤12), aralkyl(C≤18), heteroaryl(C≤12), heteroaralkyl(C≤18), or a substituted version thereof;
• or —Y1—Ra, wherein:
• Y1 is alkanediyl(C≤12), arenediyl(C≤12), or a substituted version of either group;
• Ra is aralkyl(C≤12), heterocycloalkyl(C≤12), aralkoxy(C≤12), -aralkyl(C≤12)-heterocycloalkyl(C≤8), or a substituted version thereof;
• or
• a group of the formula:
• wherein:
• X1 and X2 is C or N;
• R10 is alkyl(C≤12), cycloalkyl(C≤12), aryl(C≤12), heteroaryl(C≤12), aralkyl(C≤18), acyl(C≤12), heteroarenediyl(C≤12)-heteroaryl(C≤12), —C(O)-diarylamino(C≤12), —C(O)-heteroaryl(C≤12), alkylsulfonyl(C≤12), arylsulfonyl(C≤12), heteroarylsulfonyl(C≤12), alkylsulfonylamino(C≤12), or a substituted version of any of these groups;
• an amino protecting group;
• or
• a compound of the formula:
• wherein:
• R1 and R2 are each independently hydrogen, alkyl(C≤8), substituted alkyl(C≤8), acyl(C≤8), or substituted acyl(C≤8);
• R3 is —S(O)xRb, wherein:
• x is 0, 1, or 2;
• Rb is hydrogen or alkyl(C≤12), aryl(C≤12), aralkyl(C≤12), heteroaryl(C≤12), heteroaralkyl(C≤12), or a substituted version of any of these groups;
• R4 is hydrogen, alkyl(C≤8), substituted alkyl(C≤8), —S(O)yRc, wherein:
• y is 0, 1, or 2;
• Rc is hydrogen or alkyl(C≤12), aryl(C≤12), aralkyl(C≤12), heteroaryl(C≤12), heteroaralkyl(C≤12), or a substituted version of any of these groups;
• and
• R5 and R6 are each independently hydrogen, alkyl(C≤8), substituted alkyl(C≤8), aryl(C≤12), substituted aryl(C≤12), acyl(C≤8), or substituted acyl(C≤8);
• provided that the compound is not a compound of the formula:
• or a pharmaceutically acceptable salt thereof.