Dimethyltryptamine analogues as nitric oxide delivery drugs
AssigneeAtai Therapeutics, Inc.
InventorsRobert B. Perni, Glenn Short, Tanweer A. Khan
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Abstract
Provided herein are compounds of Formula (I), (II), or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I), (II), or a pharmaceutically acceptable salt thereof.
Claims34
A method of treating a mental health disease or disorder, the method comprising administering to a subject in need thereof a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof;
- wherein,
- R3, R4, and R5 are independently H, halogen, or C1-C6 alkyl;
- R6 is —(C═O)(CR7R7′)n—ONO2, or —(C═O)(CR7R7′)m—CH(NH2)CH2ONO2;
- R1 and R2 are each independently H or C1-C6 alkyl;
- and
- R7 and R7′ are independently H, halogen, or C1-C6 alkyl;
- X, Y, and Z are independently absent or O;
- m is 2, 3, or 4;
- and
- each n is independently 1, 2, 3, 4 or 5.
A method of treating a mental health disease or disorder, the method comprising administering a therapeutically effective amount of a compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.