Methods of treating cancer

A compound having Formula I:

• or a pharmaceutically acceptable salt thereof, wherein X is:
• each of R1, R2 R3, R4, and R5 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted alkylamino, substituted or unsubstituted aminoalkoxy, and substituted or unsubstituted alkylthiol, provided that at least one of R1, R2 R3, R4, and R5 is unsubstituted C1-3alkoxy;
• and
• each of R7, R8, R9, and R12 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, and substituted or unsubstituted amine.

A method of treating cancer in a mammal in need thereof, the method comprising administering to the mammal a compound having Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• X is:
• each of R1, R2 R3, R4, and R5 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted alkylamino, substituted or unsubstituted aminoalkoxy, and substituted or unsubstituted alkylthio, provided that at least one of R1, R2 R3, R4, and R5 is unsubstituted C1-3alkoxy;
• R6 is selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted alkylamino, and substituted or unsubstituted aminoalkoxy;
• each of R7, R8, R9, and R12 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, and substituted or unsubstituted amine;
• and
• R10 and R11 are, independently, selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl, or together with the nitrogen to which they are bonded form a substituted or unsubstituted heteroaryl or a substituted or unsubstituted heterocycloalkyl;
• wherein the cancer is selected from the group consisting of melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma.