Template based artifact reduction in neuromodulation applications
AssigneeBoston Scientific Neuromodulation Corporation
InventorsAndrew Haddock, Sandeep Avvaru
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Abstract
Methods and systems for recording evoked potentials evoked during electrical stimulation of a patient's neural tissue are disclosed. The methods and systems are useful with treatment modalities, such as spinal cord stimulation (SCS). The disclosed methods and system allow for stimulation artifacts to be reduced in, or removed from, the recorded signals. A residual portion of the stimulation artifact can be modeled and subtracted from a recorded signal that includes both artifact and neural response contributions.
Claims16
A system for providing electrical stimulation to a patient's spinal cord using one or more electrode leads implantable in the patient's spinal column, each electrode lead comprising a plurality of spinal electrode contacts, the system comprising:
- a neurostimulator that is connectable to the one or more electrode leads, and control circuitry configured to:
- cause the neurostimulator to use one or more of the spinal electrode contacts to provide a first electrical stimulation to the patient's spinal cord, wherein the first electrical stimulation is configured to evoke a first stimulation artifact but not to evoke a detectable neural response in the patient's spinal cord,
- cause the neurostimulator to use a second one or more of the spinal electrode contacts to record a first signal comprising a first stimulation artifact component,
- fit the first signal to a mathematical model to yield a template signal, wherein the mathematical model comprises an exponential decay,
- cause the neurostimulator to use one or more of the spinal electrode contacts to provide second electrical stimulation to the patient's spinal cord, wherein the second electrical stimulation is configured to evoke a second stimulation artifact and a neural response in the patient's spinal cord,
- cause the neurostimulator to use a one or more of the spinal electrode contacts to record a second signal comprising a second stimulation artifact component and a neural response component,
- use the second signal and the template signal to determine a third signal, wherein the third signal comprises the neural response component and comprises a smaller stimulation artifact component than does the second signal,
- determine one or more features of the third signal, and
- use the one or more features of the third signal for closed loop feedback adjustment of therapeutic stimulation.
A method for providing electrical stimulation to a patient's spinal cord using one or more electrode leads implantable in the patient's spinal column, each electrode lead comprising a plurality of spinal electrode contacts, the method comprising:
- using one or more of the spinal electrode contacts to provide a first electrical stimulation to the patient's spinal cord, wherein the first electrical stimulation is configured to evoke a first stimulation artifact but not to evoke a detectable neural response in the patient's spinal cord,
- using a second one or more of the spinal electrode contacts to record a first signal comprising a first stimulation artifact component,
- fitting the first signal to a mathematical model to yield a template signal, wherein the mathematical model comprises an exponential decay,
- using one or more of the spinal electrode contacts to provide second electrical stimulation to the patient's spinal cord, wherein the second electrical stimulation is configured to evoke a second stimulation artifact and a neural response in the patient's spinal cord,
- using a one or more of the spinal electrode contacts to record a second signal comprising a second stimulation artifact component and a neural response component, and
- using the second signal and the template signal to determine a third signal, wherein the third signal comprises the neural response component and comprises a smaller stimulation artifact component than does the second signal,
- determining one or more features of the third signal, and
- using the one or more features of the third signal for closed loop feedback adjustment of therapeutic stimulation.
Dependencies are inferred from the claim text.