Synchronized aspiration system with catheter sensors for removal of acute blockages from blood vessels

An aspiration catheter for assisting in retrieval of a clot from a vessel of a patient, the aspiration catheter comprising:

• at least one electrode pair positioned on a first side of a wall that defines an inner lumen of the aspiration catheter, the inner lumen extending proximal along a longitudinal axis between a distal tip and a proximal hub;
• a first pressure sensor positioned at a distal portion proximal the distal tip and within the inner lumen of the aspiration catheter;
• a second pressure sensor positioned at a distal portion proximal the distal tip on an opposed side of the wall that defines an exterior surface of the aspiration catheter;
• a third pressure sensor positioned at a proximal portion of the aspiration catheter on the exterior surface of the aspiration catheter;
• and
• a seal located on an exterior surface of the aspiration catheter, the seal being configured to seal against the lumen of an outer catheter such that an aspiration applied through the outer catheter is transferred to the aspiration catheter.