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US 12,605,486 B2Granted
Afibrotic compounds, devices, and uses thereof
AssigneeSigilon Therapeutics, Inc.
InventorsRichard Heidebrecht, Robert James Miller, Omid Veiseh
Life of this patent
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Abstract
Described herein are compounds of Formula (I), modified polymers and implantable elements comprising compounds of Formula (II), as well as compositions and methods of use thereof. In particular, the compounds, modified polymers, implantable elements and related compositions may be used in methods for the prevention and treatment of a disease, disorder or condition in a subject.
Claims8
An alginate modified with a compound of Formula (II-b):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring M1 is phenyl optionally substituted with one R3;
- Ring Z1 is selected from
- each of R2a, R2b, R2c, and R2d is independently hydrogen or alkyl;
- X is O;
- R3 is heteroalkyl,
- RC is hydrogen or alkyl;
- n is 1;
- m is 1 or 2;
- and,
- “” refers to a connection to an attachment group or the alginate provided that the compound is not
- and,
- when Z1 is
- then one or more of following apply:
- (i) the triazolyl ring is
- (ii) one of R2a or R2b is not hydrogen;
- or
- (iii) Ring M1 is substituted with 1 R3.
15 more elements
An alginate modified with a compound of Formula (II-b):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring M1 is phenyl optionally substituted with one or more R3;
- Ring Z1 is heterocyclyl optionally substituted with 1-5 R5;
- each of R2a, R2b, R2c, and R2d is independently hydrogen, alkyl, or heteroalkyl, or each of R2a and R2b or R2c and R2d is taken together to form an oxo group;
- X is absent;
- each R3 and R5 is independently alkyl, heteroalkyl, halogen, oxo, —ORA1, —C(O)ORA1, or —C(O)RB1, wherein each alkyl and heteroalkyl is optionally substituted with one or more halogen, oxo, cyano, cycloalkyl, or heterocyclyl;
- or two R5 are taken together to form a 5-6 membered ring fused to Ring Z1;
- RC is hydrogen or alkyl;
- each RA1 and RB1 is independently hydrogen, alkyl, or heteroalkyl;
- m and n are each independently 1, 2, 3, 4, 5, or 6;
- and
- “” refers to a connection to an attachment group or the alginate.
9 more elements
Dependencies are inferred from the claim text.