Nanoparticles to promote wound healing and antimicrobial infection control
AssigneeKismet Technologies Inc.
InventorChristina H. Drake
Life of this patent
Estimating the term…
Abstract
A wound healing composition is provided that includes a tissue adhesive or epithelial tissue healing agent and metal-modified cerium oxide nanoparticles (mCNPs). The nCNPs have a predominant 3+ surface charge and are in a range of about 3-35 nanometers (nm) in size and mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive or epithelial tissue healing agent and the mCNPs. The metal (m) is a stable metallic metal with antimicrobial properties and non-ionizing. The mCNPs includes AgCNP2. A method is provided that uses the healing composition to treat a wound or epithelial tissue. The composition can be used to treat the skin or eye and/or subcutaneous tissue.
Claims22
A wound healing composition comprising:
- a tissue adhesive;
- and
- silver-modified cerium oxide nanoparticles (AgCNPs) consisting of a predominant Ce3+ surface charge mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive and the AgCNPs wherein the AgCNPs include stable metallic silver (Ag) that is non-ionizing, a Janus-type two-phase construct and an antimicrobial promoting metal wherein about is at least one of 30%, 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05%, or 0.01% of the range.
A wound healing composition comprising:
- an epithelial tissue healing agent;
- and
- silver-modified cerium oxide nanoparticles (AgCNPs) consisting of a predominant Ce3+ surface charge mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the epithelial tissue healing agent and the AgCNPs wherein the AgCNPs include a stable metallic silver (Ag) that is non-ionizing and a Janus-type two-phase construct wherein about is at least one of 30%, 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05%, or 0.01% of the range.
A wound healing composition consisting of:
- a tissue adhesive;
- and
- metal-modified cerium oxide nanoparticles (mCNPs) consisting of a predominant Ce3+ surface charge mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive and the mCNPs wherein the m is an antimicrobial promoting metal consisting of one of silver, gold, or platinum wherein about is at least one of 30%, 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05%, or 0.01% of the range.
Dependencies are inferred from the claim text.