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US 12,605,480 B2Granted
Tough gel-based drug delivery compositions and methods thereof
AssigneePresident and Fellows of Harvard College
InventorsBenjamin Ross Freedman, David J. Mooney
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Abstract
Described herein are tough gel compositions that comprise an interpenetrating networks (IPN) hydrogel. The IPN hydrogel comprises a first polymer network (covalently crosslinked) and a second polymer network (ionically crosslinked), at least one therapeutic agent, and a clay material. The tough gel compositions may further include an adhesive polymer layer attached to the IPN hydrogel. Methods of use of these compositions, such as for extended release drug delivery, are also described.
Claims17
An interpenetrating networks (IPN) hydrogel composition, comprising:
- a first polymer network and a second polymer network;
- and
- at least one therapeutic agent, wherein
- wherein the first polymer network comprises a first polymer that is covalently crosslinked and the second polymer network comprises a second polymer that is ionically crosslinked;
- and
- wherein the therapeutic agent is released from the IPN hydrogel composition in a sustained manner;
- wherein the concentration of the therapeutic agent (the therapeutic agent/hydrogel w/v %) is at least about 2 times, about 4 times, about 8 times, about 16 times, about 25 times, about 50 times, about 100 times, about 200 times, about 500 times, about 1000 times, about 2000 times, about 5000 times, about 10000 times, about 20000 times, or about 25000 times greater than the solubility limit of the therapeutic agent;
- and
- wherein the therapeutic agent forms an aggregate suspended in the IPN hydrogel.
6 more elements
Dependencies are inferred from the claim text.