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US 12,605,471 B2Granted
Cromolyn derivatives and related methods of imaging and treatment
AssigneeThe General Hospital Corporation
InventorDavid R. Elmaleh
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Abstract
Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: wherein X is OH, C1-C6 alkoxyl; Y and Z are independently selected from a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2 , or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
Claims6
A method for treating neuroinflammation in a subject in need thereof comprising the steps of:
- a) administering to the subject by oral inhalation a dry powder formulation comprising 17.1 mg of micronized cromolyn sodium, 12.8 mg lactose monohydrate, and 0.6 mg micronized magnesium stearate;
- and
- b) administering orally to the subject 1 mg, 2 mg, 5 mg, 10 mg, or 25 mg of a non-steroidal anti-inflammatory drug,
- wherein neuroinflammation is treated in the subject.
1 more element
Dependencies are inferred from the claim text.