Nanodroplet with layer-by-layer assembly
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsTerry O. Matsunaga, Pedro Alcaraz, Russell S. Witte
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Abstract
The present disclosure provides novel modified nanodroplets with a layerby-layer (LBL) assembly formulation (“LBLnNDs”). The LBLnNDs of the present disclosure comprise gaseous perfluorocarbon core, polymer shell, and multiple alternating positively and negatively charged biopolymer layers dispersed layerby-layer onto the shell of the LBLnNDs. Methods of making and use of the LBLnNDs are also provided.
Claims20
A nanodroplet comprising a core comprising gas phase-change contrast agent (PCCA) and a shell membrane consisting of an anionic lipid and a cationic lipid with layer-by-layer (LBL) alternating positive and negatively charged biopolymer layers attached thereon, wherein said nanodroplet increases thermal stability yet retains acoustic activation requirement.
A nanodroplet comprising:
- a) a gaseous perfluorocarbon core;
- b) a shell membrane consisting of 1,2-dipalmitoyl phosphatidylcholine (DPPC) and dimethyldioctadecyl ammonium bromide (DDAB);
- and
- c) layer-by-layer (LBL) alternating positively and negatively charged biopolymer layers attached to the shell membrane.
Dependencies are inferred from the claim text.