Oxazine-based fluorophore compounds for nerve-specific imaging

A compound of Formula (II):

• wherein:
• R1 is selected from the group consisting of a straight or branched C1-C6 alkyl;
• —(CH2)n1—SO3−;
• —(CH2)n1—N+(CH3)3;
• —CH2—CH2—O—X1;
• —CH2—CH2—O—[CH2—CH2—O]n2—X1;
• —CH2—CH2—CH2—O—X1;
• and —CH2—CH2—CH2—O—[CH2—CH2—CH2—O]n3—X1;
• or a moiety selected from the group consisting of:
• R4 and R5, together with the nitrogen atom to which they are bound, form a ring selected from the group consisting of:
• R6 is hydrogen;
• X1 in each instance is independently selected from the group consisting of C1-C6 straight or branched alkyl, C1-C6 straight or branched alkenyl, C1-C6 straight or branched alkynyl, and —Si(C1-C4 alkyl)3;
• n is an integer selected from the group of 1 and 2;
• n1 is an integer independently selected in each instance from the group consisting of 1, 2, 3, and 4;
• n2 is an integer independently selected in each instance from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
• n3 is an integer independently selected in each instance from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
• n4 is an integer independently selected in each instance from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
• and
• with the proviso that the sum of n2+n2 is not greater than 10;
• with the proviso that the sum of n2+n3 is not greater than 10;
• with the proviso that the sum of n2+n4 is not greater than 10;
• and
• with the proviso that the sum of n3+n4 is not greater than 10.