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AssigneeThe Johns Hopkins University
InventorsJordan J. Green, Kelly Rhodes, Randall A. Meyer, Stephany Yi Tzeng
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Biodegradable particles for interacting with immune cells to generate an immunosuppressive effect are disclosed. The biodegradable particle comprises a polyester or polyester blend with at least one soluble protein or small molecule encapsulated within the particle and at least two types of protein attached to a surface of the particle or to a coating on the surface thereof, which can be used to induce targeting regulatory T cells (Tregs). The at least two types of protein attached to a surface of the particle or to a coating on the surface thereof include a “Signal 1” protein that binds to an immune cell and a “Signal 2” protein that acts as a co-stimulatory molecule to immune cells. The encapsulated protein can be an interleukin and/or a cytokine. Methods of their use for treating a disease or condition, including an autoimmune disease, are disclosed.
A biodegradable particle comprising a blend of a polyester and a poly(beta-amino ester) (PBAE) with at least one soluble protein or small molecule encapsulated within the particle and at least two types of protein attached to a surface of the particle or to a coating on the surface thereof, wherein the at least two types of protein attached to a surface of the particle or to a coating on the surface thereof include a “Signal 1” protein that binds to an immune cell and a “Signal 2” protein that acts as a co-stimulatory molecule to immune cells, and wherein the Signal 1 protein and the Signal 2 protein have a ratio of Signal 1 protein to Signal 2 protein selected from about 1:1, 1.5:1, 2:1, 5:1, and 10:1.
Dependencies are inferred from the claim text.