Porous silicon nanoparticle-based drug delivery system inducing reactive oxygen species and self-activation thereof, and method for preparing same

A pharmaceutical composition for treating pancreatic cancer comprising a drug delivery system comprising:

• a porous silicon nanoparticle;
• an isothiocyanate moiety conjugated to the surface of the porous silicon nanoparticle,
• wherein the drug delivery system further comprises a prodrug supported on the porous silicon nanoparticle, and
• a tumor homing peptide conjugated to the surface of the porous silicon nanoparticle,
• wherein the tumor homing peptide consists of a peptide having an amino acid sequence consisting of CGKRK (SEQ ID NO.1,
• wherein the prodrug is converted into an active drug by removing a promoiety ester-bonded with a parent drug by reactive oxygen species,
• wherein the parent drug is 7-ethyl-10-hydroxycamptothecin,
• wherein the promoiety is mefenamic acid
• wherein the parent drug is a camptothecin-based anticancer agent, and
• wherein the drug delivery system is represented by the following Formula 2,
• in Formula 2, pSiNP is the porous silicon nanoparticle,
• the R 1 —N═C═S is the isothiocyanate moiety,
• the isothiocyanate moiety is derived from triethoxy(3-isothiocyanatopropyl)silane),
• the R 1 is propyl,
• the THP is the tumor homing peptide,
• the L is a PEG linker, and X is 1.