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US 12,605,461 B2Granted
Hydrogel compositions and uses thereof
AssigneeMolly Sandra Shoichet
InventorsMolly Sandra Shoichet, Alexander Edgar Gilbert Baker, Roger Yue Tam
Life of this patent
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Abstract
The present invention relates to cross-linked polymers (e.g., hydrogels) including hyaluronan polymer and multimeric cross-linker for treating disorders (e.g., retinal detachment or osteoarthritis), for use in screening models (e.g., in vitro cell culture system), or for cell transplantation (e.g., in vivo cell delivery).
Claims14
A compound of formula (I):
- HAP-K (I),
- wherein
- HAP is a hyaluronan polymer;
- and
- K is a moiety covalently linked to the hyaluronan polymer having the structure of formula (Ia) or formula (Ib):
- wherein
- RX is C1-20 alkylene, C2-20 alkenylene, C2-20 alkynylene, C1-20 heteroalkylene, C2-20 heteroalkenylene, or C2-20 heteroalkynylene, any of which is optionally substituted with one or more of oxo, halogen, hydroxyl, alkoxy, azido, cyano, nitro, amino, and thiol;
- and
- R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, C2-6 heteroalkenyl, C2-6 heteroalkynyl, C3-10 carbocyclyl, C6-10 aryl, C2-9 heterocyclyl, or C2-9 heteroaryl, any of which is optionally substituted with one or more of oxo, halogen, hydroxyl, alkoxy, azido, cyano, nitro, amino, and thiol,
- or a salt thereof.
7 more elements
Dependencies are inferred from the claim text.