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US 12,605,454 B2Granted
Modified virus-like particles of CMV
AssigneeSaiba GmbH
InventorsMartin Bachmann, Andris Zeltins, Paul Pumpens
Life of this patent
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Abstract
The present invention relates to virus-like particles of plant virus Cucumber Mosaic Virus (CMV), and in particular to modified VLPs of CMV comprising Th cell epitopes, in particular universal Th cell epitopes. Furthermore, these modified VLPs serve as, preferably, vaccine platform, for generating immune responses, in particular antibody responses, against antigens linked to said modified VLPs. The presence of the Th cell epitopes, in particular universal Th cell epitopes, led to a further increase in the generated immune response.
Claims23
A composition for administration to a target species comprising:
- (a) a modified virus-like particle of cucumber mosaic virus (CMV), wherein said modified VLP of CMV comprises at least one modified CMV polypeptide, wherein said modified CMV polypeptide comprises,
- (i) a CMV polypeptide, wherein said CMV polypeptide comprises an amino acid sequence of a coat protein of CMV comprising SEQ ID NO:
- 1 or an amino acid sequence with a sequence identity of at least 90% of SEQ ID NO:1;
- and
- (ii) a T helper (Th) cell epitope;
- and
- and wherein said modified virus-like particle comprises at least one first attachment site;
- and
- (b) at least one antigen, wherein said antigen comprises at least one second attachment site;
- and
- wherein said T helper (Th) cell epitope is distinct from said amino acid sequence of a coat protein of CMV, wherein the antigen is interleukin-31 (IL-31);
- wherein the IL-31 is endogenous to said target species;
- wherein (a) and (b) are linked through said at least one first and said at least one second attachment site;
- and wherein the T helper cell epitope and the at least one antigen are different.
11 more elements
Dependencies are inferred from the claim text.