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US 12,605,452 B2Granted
Compounds that degrade kinases and uses thereof
AssigneesRegents of the University of Minnesota, The Regents of the University of California
InventorsDaniel A. Harki, Jian Tang, Ramkumar Moorthy, Rommie E. Amaro, Ozlem Demir
Life of this patent
Estimating the term…
Abstract
The disclosure is directed to compounds of the Formula (I) or (II): A-L1-B, A′-L1-B, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein A is an Aurora A ligand, A′ is a CDK4/6 ligand; B is an E3 ligase ligand; and L1 is a linker, as well as pharmaceutical compositions comprising such compounds, and methods for treating cancer using such compounds.
Claims13
A compound of the Formula:
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- the dashed line can form a double bond;
- R7 and R8 are each, independently H, alkyl, aryl, amino, acyl or amido;
- X5 is N—Z1 or CH—Z1, wherein Z1 is a cycloalkyl group;
- X1 and X2 each independently CH or N;
- X3 is -alkyl-, —O—, —S— or NR4, wherein R4 is H or alkyl;
- X4 is CH;
- R1 is H, halo, amino, alkyl, aryl or heterocyclyl;
- L1 is acyl, alkyl, alkenyl or alkynyl, and combinations thereof, optionally interrupted by one or more heteroatoms;
- Y1 is CH2 or C(O);
- X8 and X9 are each independently CR16R17, wherein R16 and R17 are each independently H, alkyl or, R16 and R17 together with the atom to which they are attached form a C(O) group;
- X10 is N or CR18, wherein R18 is H or alkyl;
- Y2 is NR19, wherein R19 is H or alkyl.
10 more elements
Dependencies are inferred from the claim text.