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US 12,605,449 B2Granted
Drug-clay mineral complex containing phospholipid and oral administration composition including same
AssigneeKorea Institute of Geoscience and Mineral Resources
InventorsJae Hwan Kim, Il Mo Kang, Dae Duk Kim, Jang Ik Lee, Gyu Ho Kim, Min Jun Baek, Chang Yun Park, Ki Min Roh, Sung Man Seo
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Abstract
According to one embodiment of the present invention, provided is a drug-clay mineral complex, in which the complex comprises a phospholipid, and the drug has an amine group.
Claims9
A drug-clay mineral complex, wherein the complex contains a phospholipid, and wherein:
- the drug in the drug-clay mineral complex is present in an amorphous state in a layered structure of the clay mineral,
- said drug has an amine group and is at least one selected from the group consisting of quetiapine, ciprofloxacin, docetaxel, camptothecin, carbamazepine, and
- said phospholipid is phosphatidylcholine, and the clay mineral is bentonite.
A method of preparing a drug-clay mineral complex comprising:
- preparing a phospholipid-clay mineral complex by mixing a phospholipid aqueous solution prepared by dissolving a phospholipid in an organic solvent and a hydrophilic solvent and a clay mineral suspension;
- preparing an aqueous drug solution by dissolving a drug compound having an amine group in a hydrophilic solvent;
- and
- mixing the aqueous drug solution and a suspension of the phospholipid-clay mineral complex, wherein:
- the drug in the drug-clay mineral complex has an amine group and is at least one selected from the group consisting of quetiapine, ciprofloxacin, docetaxel, camptothecin, carbamazepine, and
- said phospholipid is phosphatidylcholine, and the clay mineral is bentonite.
3 more elements
Dependencies are inferred from the claim text.