PSMA-targeted immunotherapies for cancers

A recombinant nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a CD3 zeta signaling domain, a costimulatory signaling domain, a transmembrane domain, and a prostate-specific membrane antigen (PSMA) binding domain, wherein the PSMA binding domain comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH and VL comprise the amino acid sequences of SEQ ID NOs:

• 12 and 14, 16 and 18, 20 and 22, 24 and 26, or 28 and 30, respectively.