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US 12,605,444 B2Granted
Adenoviral vectors encoding hepatitis B viral antigens fused to herpes virus glycoprotein D and methods of using the same
AssigneesVirion Therapeutics, LLC, The Wistar Institute
InventorsHildegund CJ Ertl, Colin Stephen Magowan
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Abstract
Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.
Claims23
A fusion protein comprising:
- an HBV polymerase N-terminal domain comprising the amino acid sequence of SEQ ID NO:
- 178, an HBV polymerase C-terminal domain comprising the amino acid sequence of SEQ ID NO:
- 179, and an HBV Core protein comprising the amino acid sequence of SEQ ID NO:
- 180.
1 more element
Dependencies are inferred from the claim text.