Microneedle containing influenza vaccine and influenza vaccine patch containing the same
AssigneesUIF (University Industry Foundation), Yonsei University, Juvic Inc.
InventorsHyungil Jung, Huisuk Yang, Geonwoo Kang
Life of this patent
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Abstract
The present invention relates to a microneedle including an influenza vaccine and particularly a soluble microneedle including an influenza vaccine, and more specifically to a microneedle including an influenza vaccine and an influenza vaccine patch including the same that can increase the stability of the influenza vaccine and expect a higher immune effect by including a water-soluble polymer and an additive at a specific ratio, and when the microneedle including the influenza vaccine of the present invention is used, not only the stability of the vaccine is increased, but also the skin penetration and drug delivery effect are remarkably excellent.
Claims13
An influenza vaccine soluble microneedle composition comprising a support part, a middle part and a tip part,
- wherein a core part of the middle part comprises sodium hyaluronate, trehalose, sucrose and influenza vaccine,
- wherein the influenza vaccine soluble microneedle is manufactured by a method including a first dispensing step of dispensing a first composition comprising sodium hyaluronate and phosphate buffered saline on a support;
- a drying step of drying the first composition to form a support part;
- a second dispensing step of dispensing a second composition including phosphate buffer saline, sodium hyaluronate, trehalose, sucrose and influenza vaccine on the support part;
- a third dispensing step of dispensing a third composition comprising sodium hyaluronate and PBS to cover the second composition on the support part;
- and a forming step of forming step of forming a middle part by the second composition and a tip part by the third composition by fluidization, and
- and wherein the concentrations of the trehalose and sucrose are 1% to 10%, respectively in the total second composition.
Dependencies are inferred from the claim text.