SARS-CoV-2 vaccines and antibodies
AssigneeRutgers, The State University of New Jersey
InventorsStephen Anderson, Elliot Campbell
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Abstract
The invention describes a method of generating antibodies to a mixture of SARS-COV-2 peptidogenic proteins or polynucleotides encoding SARS-COV-2 peptidogenic proteins wherein the SARS-COV-2 peptidogenic protein has altered conformational dynamics as compared to a SARS-COV-2 starting protein and wherein the SARS-COV-2 peptidogenic protein has a similar conformation to the SARS-COV-2 starting protein. The SARS-COV-2 peptidogenic proteins can be used to induce an immune response, which can lead to the generation of antibodies and/or can be used to vaccinate a mammal.
Claims22
A composition comprising:
- (a) at least one SARS-CoV-2 peptidogenic protein,
- (b) one or more polynucleotides encoding the at least one SARS-CoV-2 peptidogenic protein of (a);
- or
- (c) a combination of (a) and (b);
- wherein the at least one SARS-CoV-2 peptidogenic protein comprises amino acids 319-541, 319-591, or 316-594 of SEQ ID NO:15 with at least one mutation selected from Y365L, I402V, and/or V511A, and wherein the SARS CoV-2 peptidogenic protein optionally further comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30 or 50 additional amino acid substitutions, wherein the at least one SARS CoV-2 peptidogenic protein has altered conformational dynamics as compared to a SARS-CoV-2 starting protein, and wherein the SARS-CoV-2 starting protein comprises a SARS-CoV-2 Spike fragment comprising amino acids 319-541, 319-591, or 316-594 of SEQ ID NO:15.
A SARS-CoV-2 peptidogenic protein, wherein the SARS CoV-2 peptidogenic protein comprises amino acids 319-541, 319-591, or 316-594 of SEQ ID NO:15 with at least one mutation selected from Y365L, I402V, and/or V511A, optionally wherein the SARS CoV-2 peptidogenic protein further comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30 or 50 additional amino acid substitutions, and wherein the SARS-CoV-2 peptidogenic protein optionally further comprises a C-terminal tag amino acid sequence.
Dependencies are inferred from the claim text.