Composition for preventing or treating autoimmune diseases
AssigneeStatens Serum Institut
InventorsDennis Christensen, Jes Dietrich, Gabriel Pedersen, Katharina Wørzner
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Abstract
The present invention relates to a composition for preventing or treating autoimmune diseases. In particular the present invention relates to a composition that prevents or treats the disease by specifically targeting the immune cells responsible for the autoimmune reaction. Thus one aspect relates to a composition comprising DDA and TDB or MMG, retinoic acid or analogues thereof, and at least one autoimmune antigen for use in prevention or treatment of autoimmune diseases.
Claims17
A method of treatment of an autoimmune disease in a subject in need thereof, the method comprising administering to the subject a composition comprising
- a) N,N-dimethyl-N,N-dioctadecylammonium (DDA) in an amount of 1000-4000 μg/ml,
- b) trehalose-6,6-dibehenate (TDB) in an amount of 100-1000 μg/ml,
- c) cholesterol in an amount of 500-4000 μg/ml,
- d) retinoic acid or an all-trans retinoic acid (ATRA) analogues thereof selected from a group consisting of AC261066, AM580, SR1001, CD1530, ML209 and XY018, in an amount of 1000-5000 μg/ml, and
- e) at least one autoimmune antigen which induces the autoimmune disease,
- wherein the autoimmune disease is selected from the group consisting of Rheumatoid arthritis (RA), Multiple Sclerosis (MS), Systemic Lupus Erythematosus (SLE), Juvenile idiopathic arthritis (JIA), Sjögren syndrome, Systemic Sclerosis (SSc), ankylosing spondylitis (AS), Type 1 Diabetes (TID), Autoimmune thyroid diseases (AITD), Graves' disease, Hashimoto's disease, Myasthenia Gravis, Inflammatory Bowel Diseases (IBDs), Crohn's disease, ulcerative colitis, and Psoriasis.
Dependencies are inferred from the claim text.