Kinase NEK10 and its use in treating and diagnosing bronchiectasis and other respiratory disorders
AssigneesThe General Hospital Corporation, Whitehead Institute for Biomedical Research
InventorsRaghu R. Chivukula, David M. Sabatini
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Abstract
Aspects of the present disclosure provide compositions comprising NEK10 for example, wild-type NEK10 or a hyperactive NEK10 mutant such as NEK10S684D, and methods of using such for treating a respiratory disorder such as bronchiectasis.
Claims16
A method of treating bronchiectasis, the method comprising administering to a subject in need thereof a vector comprising a nucleic acid encoding Never In Mitosis Gene A-Related Kinase 10 (NEK10).
A method of diagnosing a subject as having bronchiectasis, the method comprising:
- providing a sample from the subject;
- and
- detecting a mutation in NEK10 in the sample, wherein presence of the mutation in NEK10 indicates that the subject has bronchiectasis;
- or
- detecting a level of NEK10 in the sample and comparing the level of NEK10 in the sample to a reference level, wherein presence of a level of NEK10 in the sample that is below the reference level indicates that the subject has bronchiectasis.
A method of increasing mucociliary transport (MCT) in an airway epithelium, the method comprising administering a vector comprising a nucleic acid encoding NEK10 to the airway epithelium.
Dependencies are inferred from the claim text.