Peptide inhibitors targeting methyltransfer mechanism of SARS-CoV-2
AssigneeUnited Arab Emirates University
InventorAbdulla Mahboob
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Abstract
Synthetic peptides mimicking the nsp10 sequence in the region interacting with nsp16 capable of penetrating cell membranes and inhibiting SARS-CoV-2 replication for the treatment of moderate to severe COVID-19. The invention relates to peptides inhibiting SARS-CoV-2 replication, likely through inhibition of Methyltransferase complexes (NSP10/NSP16 and NSP10/NSP14). The peptide of the present invention, P3, contains sequences corresponding to amino acids 89-96 of the non-structural protein 10 (NSP10) of SARS-CoV-2, with the only Cysteine modified to a Methionine. This peptide was made based on two previous designs P1 and P2, which constituted the amino acids 68-96 of the NSP10 protein of SARS-CoV-2.
Claims12
A peptide consisting of the amino acid sequence YGRKKRRQRRRGSGFMDLKGKY (SEQ ID NO:
- 2), wherein the peptide reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof.
Dependencies are inferred from the claim text.