Polymers, compositions and methods for treating hyperuricemia
AssigneeWaterstone Pharmaceuticals(Wuhan) Co., Ltd.
InventorsYoucheng Zhou, Tongtong Li, Minglong Hu, Yan Li, Kang Bie, Ying Liang, Jian Cui, Faming Zhang
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Abstract
The disclosure provides small molecule compounds, polymers, and compositions thereof, as well as methods for preparing such polymers and compositions. Also provided is a method of using the polymers or compositions thereof for binding uric acid or precursor thereof, and/or for treating hyperuricemia, gout, and/or diseases caused by hyperuricemia.
Claims20
A grafted polytriallylamine comprising polytriallylamine, an anion, and a moiety that binds to uric acid or precursor thereof, wherein the moiety is linked to a tertiary amine of the polytriallylamine.
A method of making 4-N-(6-hexyl)-pyrimidine-2,4,6-triamine grafted polytriallylamine bicarbonate, comprising:
- (1) polymerizing triallylamine to yield polytriallylamine;
- and
- (2) reacting 4-N-(6-bromo-hexyl)-pyrimidine-2,4,6-triamine hydrobromide with the polytriallylamine at an elevated temperature.
A method of making a grafted polytriallylamine, comprising reacting an analog of pyrimidine-2,4-diamine with polytriallylamine, wherein the analog is selected from the group consisting of:
Dependencies are inferred from the claim text.