Deoxy-cytidine or uridine derivatives for use in cancer therapies
AssigneeTetragon Bioscience Ltd.
InventorsAdam Brian Robertson, Terezia Prikrylova
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Abstract
The present invention relates to a compound of Formula (I): or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.
Claims18
A method of treating or preventing a cancer in which CDA is not over-expressed in a subject in need thereof, which comprises administering to the subject a compound of Formula (IIa):
- or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof,
- wherein:
- X is —(CH2)n—X′, wherein n is from 0 to 6 and X′ is —CHO, —OR or —OC(═O)R, where R is methyl, or n is from 1 to 6 and X′ is —OH;
- R1 is —OH or —O(P(═O)(OH)O)mH, where m is an integer having a value of from 1 to 3;
- and
- R2 is —OH.
Dependencies are inferred from the claim text.