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US 12,605,392 B1Granted
Cannabinoid composition and method of treating diabetic and chemotherapy induced neuropathic pain
AssigneeFlorida A&M University
InventorsMandip Sachdeva, Anil Kumar Kalvala
Life of this patent
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Abstract
A composition and method of treating diabetes or chemotherapy-induced neuropathy is presented. The composition is comprised of at least one extracellular vesicle encapsulating at least one cannabinoid. Administration of a therapeutically effective amount of this composition of extracellular vesicles encapsulating at least one cannabinoid can be used to treat both diabetic and chemotherapy-induced neuropathic pain in a patient.
Claims9
A composition comprising:
- (a) exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs), the exosomes having a mean particle size of 131.9±1.1 nm and a zeta potential of −30.26±0.12 mV;
- (b) cannabidiol (CBD) encapsulated within the exosomes, the CBD having been loaded by sonication at 20% amplitude with three cycles of 30 seconds on and 30 seconds off and a 5-minute cooling interval between cycles;
- (c) 0.1% (w/v) bovine serum albumin and 10% (w/w) sucrose present as stabilizers;
- (d) a pharmaceutically acceptable carrier;
- and
- (e) the composition exhibits an entrapment efficiency of at least 90% as determined by ultrafiltration with reverse-phase HPLC quantitation.
3 more elements
A composition comprising cannabidiol (CBD)-loaded exosomes, wherein:
- a) the exosomes are derived from human umbilical cord mesenchymal stem cells (hUCMSCs);
- b) the composition comprises 0.1% (w/v) bovine serum albumin and 10% (w/w) sucrose as stabilizers;
- c) the CBD is encapsulated within the exosomes in an amount effective to provide an entrapment efficiency of at least 90% as determined by ultrafiltration with reverse-phase HPLC quantitation;
- d) the CBD-loaded exosomes have a mean particle size of 131.9±1.1 nm and a zeta potential of −30.26±0.12 mV;
- e) cumulative CBD release at 24 hours is 50.74±2.44% at pH 6.8 and 53.99±1.4% at pH 7.4;
- and
- f) the composition is stable without precipitation for several months at 4° C.
4 more elements
Dependencies are inferred from the claim text.