Treatment of cancer and inhibition of metastasis
AssigneeCelex Oncology Innovations Limited
InventorsCarsten Faltum, Leif Helth Jensen, Mustafa Djamgoz
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Abstract
Compounds and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part, thereby inhibiting the metastatic and invasive growth of malignant cells in a cancer patient.
Claims21
A method for inhibiting the metastatic and invasive growth of malignant cells in a cancer patient suffering from an Nav1.5 expressing cancer, comprising administering to the patient a therapeutically effective amount of a compound of the formula I,
- wherein R1 is trifluoromethyl or trifluoromethoxy, or a pharmaceutically acceptable salt thereof,
- wherein the therapeutically effective amount reduces the persistent part of the Nav1.5 current without eliminating the transient part of the current.
A method for inhibiting the metastatic and invasive growth of malignant cells in a cancer patient suffering from a neonatal Nav1.5 expressing cancer, comprising administering to the patient a therapeutically effective amount of a compound of the formula Ia,
- or a pharmaceutically acceptable salt thereof,
- wherein the therapeutically effective amount decreases the expression of neonatal Nav1.5.
A method of decreasing the expression of neonatal Nav1.5 on Nav1.5 expressing cancer cells in a patient suffering from a Nav1.5 expressing cancer, comprising administering to the patient a therapeutically effective amount of a compound of the formula Ia,
- or a pharmaceutically acceptable salt thereof,
- thereby inhibiting the metastatic and invasive growth of malignant cells of the Nav1.5 expressing cancer in the patient.
Dependencies are inferred from the claim text.