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US 12,605,385 B2Granted
Methotrexate formulation
AssigneeShorla Pharma Ltd.
InventorsMichael Frodsham, Julie-Ann Penton
Life of this patent
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Abstract
A liquid pharmaceutical composition comprises methotrexate free acid and a buffer, wherein the pH of the composition is in the range of 6.5 to 8.2. Processes for preparation of the liquid pharmaceutical composition are also described. The liquid pharmaceutical composition is useful in therapy.
Claims16
A liquid pharmaceutical composition comprising:
- methotrexate free acid,
- 2 to 6 mg/ml polyethylene glycol, and
- a buffer,
- wherein the pH of the composition is in the range of 6.6 to 7.0, and
- wherein the buffer strength is between 0.02 to 0.06 M.
2 more elements
Dependencies are inferred from the claim text.