Methods for drug screening and compositions useful for the inhibition of cell proliferation and/or cell survival
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsGabriel Musso, Calum A. Macrae
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Abstract
The present disclosure relates to the field of drug discovery and therapeutics, including systems and methods to predict drug function, to classify or prioritize drugs based on predicted function, and to test known and novel compounds for function in a vertebrate system. The present disclosure also relates to compounds identified using the disclosed systems and methods, the novel mechanisms of action of the compounds, and applications of the compounds as therapeutics, e.g., as cancer therapeutics.
Claims16
A method for inhibiting cell proliferation, cell growth, and/or cell survival comprising:
- administering a compound of Formula I, derivatives, isomers, or pharmaceutically acceptable salts thereof, at a dosage effective to inhibit cell proliferation, cell growth, and/or survival of the cells, wherein Formula I is:
- wherein R is selected from the group consisting of:
A method of treating a disease or condition characterized by increased cell proliferation and/or cell growth in a subject in need thereof, the method comprising:
- administering to the subject an effective amount of a compound of Formula I, derivatives, isomers, or pharmaceutically acceptable salts thereof, wherein Formula I is:
- wherein R is selected from the group consisting of:
A method of reversibly decreasing the activity of phospholipase D and/or reducing the amount of phosphatidic acid in a subject in need thereof, the method comprising:
- administering to the subject a compound of Formula I, derivatives, isomers, or pharmaceutically acceptable salts thereof, at a dosage effective to reversibly decrease the activity of phospholipase D and/or reduce the amount of phosphatidic acid, wherein Formula I is:
- wherein R is selected from the group consisting of:
A method of increasing the activity of phospholipase A and/or phospholipase C in a population of cells, the method comprising:
- administering to the population of cells a compound of Formula I, derivatives, isomers, or pharmaceutically acceptable salts thereof, at a dosage effective to increase the activity of phospholipase A and/or phospholipase C, wherein Formula I is:
- wherein R is selected from the group consisting of:
Dependencies are inferred from the claim text.