Losartan liquid formulations and methods of use
AssigneeScienture, Inc.
InventorsBhavya Teja Kolla, Rahul Surana, Suketu Sanghvi, Jigar Bhatt
Life of this patent
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Abstract
The present disclosure relates to stable, liquid pharmaceutical compositions of losartan or pharmaceutically acceptable salts thereof for oral administration. The present disclosure further provides powder compositions for reconstitution to provide a liquid formulation. In further aspects, the present disclosure relates to processes for preparation of such pharmaceutical compositions, and methods of treating a subject in need of losartan by administration of a formulation described herein.
Claims20
A method of treating hypertension comprising administering to a human in need thereof an oral pharmaceutical composition comprising:
- about 10 mg/mL of losartan or a pharmaceutically acceptable salt thereof,
- a suspending agent selected from the group consisting of hydroxyethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, microcrystalline cellulose, sodium carboxymethylcellulose, xanthan gum, acacia, an alginate, and guar gum, or a combination thereof;
- a pH modifying agent;
- a preservative;
- and
- a solubilizer,
- wherein the pharmaceutical composition is a liquid suspension, and
- wherein the liquid suspension has a pH of about 7.
A method of treating nephropathy comprising administering to a human in need thereof an oral pharmaceutical composition comprising:
- about 10 mg/mL of losartan or a pharmaceutically acceptable salt thereof,
- a suspending agent selected from the group consisting of hydroxyethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, microcrystalline cellulose, sodium carboxymethylcellulose, xanthan gum, acacia, an alginate, and guar gum, or a combination thereof;
- a pH modifying agent;
- a preservative;
- and
- a solubilizer,
- wherein the pharmaceutical composition is a liquid suspension, and
- wherein the liquid suspension has a pH of about 7.
A method of treating hypertension or diabetic nephropathy comprising administering to a human in need thereof an oral pharmaceutical composition comprising:
- about 10 mg/mL of losartan potassium,
- a suspending agent selected from the group consisting of hydroxyethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, microcrystalline cellulose, sodium carboxymethylcellulose, xanthan gum, acacia, an alginate, and guar gum, or a combination thereof;
- a pH modifying agent;
- a preservative;
- a solubilizer;
- an emulsifying agent;
- and
- a crystallization inhibitor,
- wherein the pharmaceutical composition is a liquid suspension, and
- wherein the liquid suspension has a pH of about 7.
Dependencies are inferred from the claim text.