Methods of treating pancreatic cancer
AssigneePanTher Therapeutics, Inc.
InventorsLaura Indolfi, Margaret Lashof-Sullivan
Life of this patent
Estimating the term…
Abstract
Provided are implantable and biodegradable drug delivery devices capable of delivering an active pharmaceutical ingredient (API) directly to a target pancreatic tumor tissue. The drug delivery devices can include at least two layers. One of the layers can include the API and a biodegradable polymer and a second layer can include another biodegradable polymer that degrades slower than the first biodegradable polymer. When the device is placed directly on the target tissue, the API layer can degrade thereby releasing the API towards the target tissue while the non-API layer can prevent the API from being released away from the target tissue onto non-target tissue.
Claims16
A method of treating pancreatic cancer comprising:
- implanting a drug delivery device in a peritumoral area of the pancreas of a patient, wherein the drug delivery device comprises:
- a first layer comprising an active pharmaceutical ingredient (API), a first solvent, and at least 70 wt. % of a first biodegradable polymer;
- and
- a second layer on a side of the first layer, the second layer comprising a second solvent and at least 85 wt. % of a second biodegradable polymer;
- wherein the API is released from the drug delivery device into a tumor of the pancreas by in vivo degradation of the first biodegradable polymer.
Dependencies are inferred from the claim text.