Compositions and methods for inhibiting blood cancer cell growth
AssigneeUniversity of New Brunswick
InventorsAlli Murugesan, Anthony Reiman, Mohamed Touaibia
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Abstract
Methods, compositions and uses for inhibiting the growth in blood cancer cells in a patient with one or more of a caffeic acid phenpropyl ester (GL8) analogue selected from the group consisting of As26, J229, J91, LL27, LL23, HM7, As25, MT26, and J205. The blood cancer cells can be myeloma, lymphoma and leukemia cells. The methods, compositions and uses can be in conjunction with the use of an IMiD to treat a patient. The compositions can include a pharmaceutically acceptable carrier, adjuvant or vehicle, a pharmaceutically acceptable salt or dietary supplement.
Claims22
A method for inhibiting the growth of blood cancer cells comprising:
- contacting the cells with a caffeic acid phenpropyl ester (GL8) analogue selected from the group consisting of As26, J229, J91, LL27, LL23, As25, MT26, and J205, having the structures:
- where,
- As26:
- R2 = R3 = R5 = H, R1 = R4 = OH, A = CO, X = O, R = (CH2)3 Ph
- J229:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CH2, X = O, R = (CH2)3 Ph
- J91:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = CH2CCPh
- LL27:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = (CH2)5 Ph
- LL23:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = (CH2)4 Ph
- As25:
- R3 = R4 = R5 = H, R1 = R2 = OH, A = CO, X = O, R = (CH2)3 Ph
- MT26:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = CH2CH2 Ph(4-F)
- J205:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = CH2, R = (CH2)2 Ph
- in an amount effective to inhibit the growth.
A method for inhibiting the growth of blood cancer cells in a patient comprising:
- administering to a patient a therapeutically effective amount of a caffeic acid phenpropyl ester (GL8) analogue selected from the group consisting of As26, J229, J91, LL27, LL23, As25, MT26, and J205, having the structures:
- where,
- As26:
- R2 = R3 = R5 = H, R1 = R4 = OH, A = CO, X = O, R = (CH2)3 Ph
- J229:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CH2, X = O, R = (CH2)3 Ph
- J91:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = CH2CCPh
- LL27:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = (CH2)5 Ph
- LL23:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = (CH2)4 Ph
- As25:
- R3 = R4 = R5 = H, R1 = R2 = OH, A = CO, X = O, R = (CH2)3 Ph
- MT26:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = O, R = CH2CH2 Ph(4-F)
- J205:
- R1 = R4 = R5 = H, R2 = R3 = OH, A = CO, X = CH2, R = (CH2)2 Ph.
Dependencies are inferred from the claim text.