Transdermal drug delivery system

A method for transdermal delivery of a formulation having an active ingredient to a mammal having a body surface, the method comprises:

• a) applying the formulation to the body surface, wherein formulation comprises:
• i) at least one penetration agent;
• ii) at least one basement membrane disruptor;
• iii) at least one vaso-modulator;
• and
• iv) at least one active ingredient;
• wherein the formulation allows for penetration of the active ingredient to a dermis layer of the body surface.

A method for transdermal delivery of a formulation having an active ingredient to a mammal, said mammal having a body surface;

• the method comprises:
• a) administering at least one penetration agent to the body surface;
• b) administering at least one basement membrane disruptor to the body surface;
• c) administering at least one vaso-modulator to the body surface;
• and
• d) administering at least one active ingredient to the body surface;
• wherein the formulation allows for penetration of the active ingredient to the dermis.

A kit for transdermal delivery of an active ingredient to a mammal having a body surface;

• the kit comprises
• a) at least one penetration agent;
• b) at least one basement membrane disruptor;
• c) at least one vaso-modulator;
• and
• d) at least one active ingredient;
• wherein the kit creates a formulation that allows for penetration of the active ingredient to a dermis layer of the body surface.