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US 12,605,344 B2Granted
Nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
AssigneeThe Trustees of Princeton University
InventorsRobert F. Pagels, Robert K. Prud'Homme
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Abstract
An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.
Claims20
A nanoparticle comprising:
- a core comprising a more polar region of a linear copolymer and a water-soluble agent,
- a shell comprising a less polar region of the linear copolymer, and
- a coating,
- wherein the more polar region of the linear copolymer comprises a peptide,
- wherein the coating comprises an inner region and an outer region,
- wherein the inner region comprises a hydrophobic region of an amphiphilic polymer, and
- wherein the outer region comprises a hydrophilic region of the amphiphilic polymer.
4 more elements
Dependencies are inferred from the claim text.