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AssigneesShanghai Wei Er Biopharmaceutical Technology Co., Ltd., Shanghai Baolong Pharmaceutical Co., Ltd., Baolong Pharmaceutical Co., Ltd., Shanghai Baolong Anqing Pharmaceutical Co., Ltd.
InventorsXin Wu, Hang Chen, Xinmei Chen, Jianming Chen, Yongjie Huang, Wuhao Wei, Xinyu Wang, Mengmeng Liu
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The present invention relates to the technical field of pharmaceutics, and in particular to a triptolide lignocerate, a liposome thereof and a preparation method therefor. The chemical structural formula of the triptolide lignocerate is represented by formula (I). The triptolide lignocerate provided by the present invention is obtained by esterification of triptolide C14-OH and lignoceric acid. The anti-tumor effectiveness, safety and the like of the triptolide lignocerate liposome are further improved with respect to the prior art, so that a foundation is laid for providing safer and more effective triptolide-related clinical preparations.
A lyophilized powder comprising triptolide lignocerate, lipids, and lyoprotectant, wherein the lipids comprise all of phospholipid, cholesterol, PEG-distearoylethanolamine, and wherein liposomes are formed upon reconstitution of the lyophilized powder.
A formulation comprising liposomes comprising triptolide lignocerate and lipids, wherein the lipids comprise all of phospholipid, cholesterol, PEG-distearoylethanolamine, and wherein the formulation comprises water for injection.
Dependencies are inferred from the claim text.