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US 12,605,332 B2Granted
Transdermal delivery formulations
AssigneeAlbert Einstein College of Medicine
InventorJoel M. Friedman
Life of this patent
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Abstract
A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.
Claims26
A transdermal formulation for enhancing systemic nitric oxide (NO) in a subject, comprising:
- (a) an effective amount of an NO booster and optionally an NO precursor, wherein the NO booster comprises one or more agents selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, quercetin, berberine, resveratrol and vitamin D, and wherein the NO precursor comprises a S-nitrosothiol-containing molecule, or a thiol-containing molecule and a nitrite source;
- (b) a polyol, wherein the NO booster is dissolved in the polyol;
- and optionally
- (c) fatty acid, wherein the polyol and the fatty acid are in a ratio ranging from about 10:1 to about 50:1 by weight,
- wherein the amounts of the polyol is selected so that upon administration the effective amount of the NO booster is delivered transdermally.
2 more elements
Dependencies are inferred from the claim text.