System and method for the quantification of contrast agent

A method of contrast-enhanced radiographic image processing to assess uptake of a radio-opaque contrast agent in organ tissue in a patient including an adipose tissue and interesting tissues, wherein non-active tissues include the adipose tissue and a fibroglandular non-active tissue, active tissues include lesions and a fibroglandular active tissue, and the interesting tissues include the active tissues and a portion of the non-active tissues, wherein the method comprises:

• administering the radio-opaque contrast agent to the patient;
• taking low energy (LE) and high energy (HE) radiographic images (RI) of the organ tissue;
• quantifying the radio-opaque contrast agent only where the interesting tissues have a thickness greater than zero, the interesting tissues including fibroglandular tissue and any lesions of the organ tissue;
• adopting a relation that a total concentration of the radio-opaque contrast agent in the active tissues is a sum of a concentration of the radio-opaque contrast agent in the non-active tissues plus an additional concentration of the radio-opaque contrast agent only in the interesting tissues according to location in the HE RI;
• and
• determining the thickness of the interesting tissues by an adopting a relation that in the LE RI there is no difference between the total concentration of the radio-opaque contrast agent in the active tissues versus in the non-active tissues.