Method and apparatus for human brain neuroprotection during surgery
AssigneeKaunas University of Technology
InventorsArminas Ragauskas, Vytautas Petkus, Edvinas Chaleckas
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Abstract
The present invention is directed generally to a method and apparatus for human brain neuroprotection during surgery. The invention includes use of a heart-lung machine to generate periodic rectangular pulsation of blood flow. The invention uses a non-invasive CA monitor to continuously record transient functions such as dynamic autoregulation functions of a human brain cerebrovascular autoregulation system and process the data to generate an alarm to indicate CA impairment and take steps to minimize the CA impairment event.
Claims16
A system for human brain neuroprotection during surgery comprising a heart-lung machine that generates periodic rectangular pulsation of blood flow, the period of the rectangular pulsation of blood flow is less than one minute;
- a non-invasive CA monitor for continuously recording data of the dynamic autoregulation functions of the human brain cerebrovascular autoregulation system and monitoring of positive and negative transient functions of the patient CA system in order to reflect nonlinear dynamics of the patient CA system;
- a processor configured for processing the recorded CA transient functions data to identify a start point of a single CA impairment event and to generate an alarm;
- wherein the heart-lung machine is configured to be adjusted after the alarm to regulate the parameters of mean blood flow generated by the heart-lung machine to minimize the duration of the single CA impairment event.
A system for human brain neuroprotection during surgery comprising a heart-lung machine that generates periodic rectangular pulsation of blood flow, the period of the rectangular pulsation of blood flow is less than one minute;
- a non-invasive CA monitor for continuously recording data of the dynamic autoregulation functions of the human brain cerebrovascular autoregulation system and monitoring of positive and negative transient functions of the patient CA system in order to reflect nonlinear dynamics of the patient CA system;
- a processor configured for processing the recorded CA transient functions data to identify a start point of a single CA impairment event and to generate an alarm;
- wherein the heart-lung machine is configured to be adjusted after the alarm to regulate the parameters of mean blood flow generated by the heart-lung machine to minimize the duration of the single CA impairment event;
- and wherein the parameters of mean blood flow are regulated to reduce the CA impairment event to less than five minutes.
A system for human brain neuroprotection during surgery comprising a heart-lung machine that generates periodic rectangular pulsation of blood flow, the period of the rectangular pulsation of blood flow is less than one minute;
- a non-invasive CA monitor for continuously recording data of the dynamic autoregulation functions of the human brain cerebrovascular autoregulation system and monitoring of positive and negative transient functions of the patient CA system in order to reflect nonlinear dynamics of the patient CA system;
- a processor configured for processing the recorded CA transient functions data to identify a start point of a single CA impairment event and to generate an alarm;
- wherein the heart-lung machine is configured to be adjusted after the alarm to regulate the parameters of mean blood flow generated by the heart-lung machine to minimize the duration of the single CA impairment event;
- and wherein the start point of the single CA impairment event is identified in real-time using a transient function CA factor.
Dependencies are inferred from the claim text.