Compositions and methods for modulating microbiomes
AssigneeBoyce Thompson Institute for Plant Research, Inc.
InventorsDaniel Klessig, Murli Manohar, Frank Schroeder
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Abstract
Compositions and methods for modulating a microbiome are disclosed. In accordance with the instant invention, methods of modifying and/or modulating a microbiome (e.g., the composition of a microbiome) are provided. The methods of the instant invention comprise contacting the microbiome (e.g., the assemblage of organisms composing the microbiome) with a compound excreted by an organism (e.g., nematode), particularly an organism that naturally lives in or is part of the microbiome.
Claims26
A method of modifying the composition of a microbiome, said method comprising directly contacting the microbiome with a composition comprising an ascaroside,
- wherein the modification comprises modifying the growth of a bacterial species present in the microbiome relative to a control not treated with the composition.
A method of enhancing the growth of a crop plant comprising directly contacting microorganisms in a soil in contact with the crop plant with a composition comprising an ascaroside, wherein the enhanced growth of the crop plant is due to effects of the ascaroside on the growth of microorganisms present in the soil, wherein the effect of the ascaroside comprises modifying the growth of a bacterial species present in the soil relative to a control soil not treated with the composition.
A method of modifying the composition of a microbiome, said method comprising directly contacting the microbiome with a composition comprising an ascaroside, wherein the modification comprises modifying the growth of a bacterial species present in the microbiome relative to a control not treated with the composition, and wherein the modification comprises modifying biofilm formation by the bacterial species.
A method of enhancing the growth of a crop plant comprising contacting a soil in contact with the crop plant with a composition comprising an ascaroside, wherein the enhanced growth of the crop plant is due to effects of the ascaroside on the growth of microorganisms present in in the soil,
- wherein the effect of the ascaroside comprises modifying the growth of a bacterial species present in the soil relative to a control soil not treated with the composition, and
- wherein the modification comprises modifying biofilm formation by the bacterial species.
A method of modifying the composition of a microbiome, said method comprising contacting an assemblage of organisms composing the microbiome with a composition comprising an ascaroside,
- wherein the modification comprises modifying the growth of a bacterial species present in the microbiome relative to a control not treated with the composition,
- wherein the ascaroside is selected from the group consisting of ascr #3, ascr #9, ascr #10, and ascr #18, and
- wherein the modification comprises increasing the growth of Serratia marcescens.
Dependencies are inferred from the claim text.