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US 12,604,871 B2Granted
Animal model for amplifying human or animal circulating tumor cells
AssigneesInovotion, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1
InventorsXavier Rousset, Emilien Dosda, Jean Viallet, Léa Payen-Gay, Denis Maillet
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Abstract
The present invention relates to an avian model enabling the amplification of human or animal circulating tumour cells (CTC) and to the use thereof for monitoring and determining the sensitivity of a patient or an animal suffering from cancer to one or more therapeutic agent(s), as well as for screening novel therapeutic agents intended for the treatment of cancer.
Claims6
A method for preparing an embryonated chicken's egg model for the amplification of human or animal circulating tumor cells (CTC), said method comprising
- (i) isolating 5 to 5000 CTC from a sample of a patient or animal having cancer,
- (ii) grafting the 5 to 5000 CTC isolated from the sample on the chorioallantoic membrane (CAM) of an embryonated chicken egg that is at 8 to 10 days of development,
- (iii) incubating the resulting grafted embryonated egg to amplify the CTC to produce a tumor, and
- (iv) collecting the tumor that develops from the amplified CTC.
1 more element
Dependencies are inferred from the claim text.