# US 12,603,175 B2 · Method and apparatus for determining diagnosis result data > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,603,175 B2 - Document ID: US12603175B2 - Status: Granted - Kind: B2 - Application number: 17/906,054 - Filed: 2021-03-23 - Published: 2024-12-12 - Granted: 2026-04-14 - Earliest claimed: 2020-03-11 - Assignees: Korea University Research and Business Foundation - Applicants: Korea University Research and Business Foundation - Inventors: Jae Young Kim; Yoo Sang Baek - Web page: https://patentgrep.com/patent/US12603175B2 ## CPC - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G06T 7/0016: {involving temporal comparison} - G16H 30/20: for handling medical images, e.g. DICOM, HL7 or PACS - G16H 30/40: for processing medical images, e.g. editing - G16H 50/30: for calculating health indices; for individual health risk assessment - G06T 2207/10048: Infrared image - G06T 2207/30088: Skin; Dermal - G06T 2207/30096: Tumor; Lesion - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL ## Abstract Disclosed is a method and apparatus for determining diagnosis result data by using a thermal image. A method for determining diagnosis result data may comprise the steps of: acquiring a first thermal image indicating a temperature change of skin, to which thermal stimulation has been applied, over time; acquiring a second thermal image indicating a temperature change of skin, to which cold stimulation has been applied, over time; extracting a temperature restoration feature of the skin from each of the first thermal image and the second thermal image; and determining diagnosis result data related to the skin on the basis of the temperature restoration feature extracted from the first thermal image and the temperature restoration feature extracted from the second thermal image. ## Claims ### Claim 1 A method of determining diagnosis result data by using a thermal image, the method comprising: obtaining a first thermal image representing a temperature change, over time, of skin to which heat stimulation is applied; obtaining a second thermal image representing a temperature change, over time, of skin to which cold stimulation is applied; extracting a temperature restoration feature of the skin from each of the first thermal image and the second thermal image by: calculating temperature change rate values by each image frame from the first thermal image and determining an average value of the temperature change rate values to be a first temperature restoration feature; calculating temperature change rate values by each image frame from the second thermal image and determining an average value of the temperature change rate values to be a second temperature restoration feature; and determining diagnosis result data related to the skin, based on a comparison of the first temperature restoration feature to a first threshold value and the second temperature restoration feature to a second corresponding threshold value, wherein the first threshold value is greater than the second threshold value, wherein the diagnosis result data indicates a presence of an abnormality when the first or second temperature restoration feature is greater than or equal to its corresponding threshold value, wherein the temperature change rate values equate to a difference in temperature between two sequential image frames divided by a time difference between the sequential image frames. ### Claim 2 (depends on 1) The method of claim 1, wherein the abnormality is a malignant lesion. ### Claim 3 (depends on 1) The method of claim 1, wherein the abnormality is vascular disease. ### Claim 4 (depends on 1) A non-transitory computer-readable storage medium storing instructions that, when executed by a processor, cause the processor to perform the method of claim 1. ### Claim 5 (depends on 1) The method of claim 1, wherein the heat stimulation is applied with a first heat stimulation probe and the cold stimulation is applied with a second cold stimulation probe separate from the first heat stimulation probe, wherein the heat stimulation and the cold stimulation are applied in parallel. ### Claim 6 A device for obtaining a thermal image for determining diagnosis result data, the device comprising: a temperature controller for transmitting, to a probe, a control signal for applying heat stimulation and cold stimulation to skin; the probe for applying heat stimulation and cold stimulation to skin, based on the control signal of the temperature controller; an infrared camera for obtaining a first thermal image from skin to which heat stimulation is applied by the probe and for obtaining a second thermal image from skin to which cold stimulation is applied by the probe; a temperature restoration feature extractor for extracting a temperature restoration feature of skin from each of the first thermal image and the second thermal image by: calculating temperature change rate values by each image frame from the first thermal image and determining an average value of the temperature change rate values to be a first temperature restoration feature; calculating temperature change rate values by each image frame from the second thermal image and determining an average value of the temperature change rate values to be a second temperature restoration feature; and a diagnosis result data determiner for determining diagnosis result data, based on a comparison of the first temperature restoration feature to a first threshold value and the second temperature restoration feature to a second corresponding threshold value, wherein the first threshold value is greater than the second threshold value, wherein the diagnosis result data indicates a presence of an abnormality when the first or second temperature restoration feature is greater than or equal to its corresponding threshold value, wherein the temperature change rate values equate to a difference in temperature between two sequential image frames divided by a time difference between the sequential image frames. ### Claim 7 (depends on 6) The device of claim 6, further comprising: a first heat stimulation probe to apply the heat stimulation; and a second cold stimulation probe to apply the cold stimulation, wherein the second cold stimulation probe is separate from the first heat stimulation probe, wherein the heat stimulation and the cold stimulation are applied in parallel. ### Claim 8 A device for determining diagnosis result data by using a thermal image, the device comprising: a thermal image receiver for receiving the first thermal image and the second thermal image from an infrared camera; a temperature restoration feature extractor for extracting a temperature restoration feature of skin from each of the first thermal image and the second thermal image by: calculating temperature change rate values by each image frame from the first thermal image and determining an average value of the temperature change rate values to be a first temperature restoration feature; calculating temperature change rate values by each image frame from the second thermal image and determining an average value of the temperature change rate values to be a second temperature restoration feature; and a determiner for determining diagnosis result data related to the skin, based on a comparison of the first temperature restoration feature to a first threshold value and the second temperature restoration feature to a second corresponding threshold value, wherein the first threshold value is greater than the second threshold value, wherein the diagnosis result data indicates a presence of an abnormality when the first or second temperature restoration feature is greater than or equal to its corresponding threshold value, wherein the temperature change rate values equate to a difference in temperature between two sequential image frames divided by a time difference between the sequential image frames. ### Claim 9 (depends on 8) The device of claim 8, wherein the abnormality is a malignant lesion. ### Claim 10 (depends on 8) The device of claim 8, wherein the abnormality is vascular disease. ### Claim 11 (depends on 8) The device of claim 8, further comprising: a first heat stimulation probe to apply heat stimulation; and a second cold stimulation probe to apply cold stimulation, wherein the second cold stimulation probe is separate from the first heat stimulation probe, wherein the heat stimulation and the cold stimulation are applied in parallel.