Program for operating cell culture support apparatus, cell culture support apparatus, and method for operating cell culture support apparatus

A cell culture support apparatus comprising:

• at least one processor,
• wherein the processor is configured to:
• acquire a learned model, derived by performing machine learning by using a set of time-series data for learning and result data as training data, the set being obtained from a storage device, the time-series data for learning indicating a time transition of an amount of each of plural types of components constituting a medium used for cell culture and the result data indicating a good result or a bad result of the cell culture performed in accordance with the time transition of the amount of each of the plural types of components of the time-series data for learning, the learned model indicating a guideline of the amount representing the amount of each of the plural types of components for obtaining the good result in the cell culture, the good result and the bad result being determined based on antibody concentration contained in the culture medium after the cell culture;
• acquire time-series data for analysis from an operator terminal, the time-series data for analysis indicating the time transition of the amount of each of the plural types of components during a period of cell culture;
• upon receiving input data for at least one of the time-series data for analysis, derive guideline information of the amount for obtaining the good result in the cell culture from the learned model and the time-series data for analysis that has been received by the time at which the input data was received, the guideline information indicating whether the amount of each of the plural types of components should be larger or less than a value obtained by the learned model;
• perform a control for outputting the guideline information to the operator terminal,
• wherein the guideline information is delivered by performing a calculation by using the input data which include a basal amount that is an amount of each of the plural types of components in a basal medium prepared prior to starting of the cell culture, a supply amount that is an amount of at least one of the plural types of components supplied every day in the period of the cell culture of a plurality of days, and a metabolic amount that is an amount that cells metabolize;
• and
• set the supply amount of each of the plural types of components based on the guideline information that was outputted and controlling a culturing device to make the culture based on the supply amount that was set.

A method for operating a cell culture support apparatus, the method comprising:

• acquiring a learned model, derived by performing machine learning by using a set of time-series data for learning and result data as training data, the set being obtained from a storage device, the time-series data for learning indicating a time transition of an amount of each of plural types of components constituting a medium used for cell culture and the result data indicating a good result or a bad result of the cell culture performed in accordance with the time transition of the amount of each of the plural types of components of the time-series data for learning, the learned model indicating a guideline of the amount representing the amount of each of the plural types of components for obtaining the good result in the cell culture, the good result and the bad result being determined based on antibody concentration contained in the culture medium after the cell culture;
• acquiring time-series data for analysis from an operator terminal, the time-series data for analysis indicating the time transition of the amount of each of the plural types of components during a period of cell culture;
• upon receiving input data for at least one of the time-series data for analysis, deriving guideline information of the amount for obtaining the good result in the cell culture from the learned model acquired and the time-series data for analysis acquired that has been received by the time at which the input data was received, the guideline information indicating whether the amount of each of the plural types of components should be larger or less than a value obtained by the learned model;
• performing a control for outputting the guideline information to the operator terminal,
• wherein the guideline information is delivered by performing a calculation by using the input data which include a basal amount that is an amount of each of the plural types of components in a basal medium prepared prior to starting of the cell culture, a supply amount that is an amount of at least one of the plural types of components supplied every day in the period of the cell culture of a plurality of days, and a metabolic amount that is an amount that cells metabolize;
• and
• setting the supply amount of each of the plural types of components based on the guideline information that was outputted and using the supply amount to make a cell culture based on the supply amount that was set.