# US 12,601,805 B2 · Dynamic contrast-enhanced magnetic resonance imaging reconstruction method and apparatus, and magnetic resonance imaging system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,601,805 B2 - Document ID: US12601805B2 - Status: Granted - Kind: B2 - Application number: 18/646,989 - Filed: 2024-04-26 - Published: 2024-10-31 - Granted: 2026-04-14 - Earliest claimed: 2023-04-28 - Assignees: Siemens Healthineers AG - Applicants: Siemens Healthineers AG - Inventors: Cai Xia Fu - Web page: https://patentgrep.com/patent/US12601805B2 ## CPC - G01R 33/5601: {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent} - G01R 33/5608: {Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels (image data processing or generation, in general G06T)} - G01R 33/56308: {Characterization of motion or flow; Dynamic imaging} - G01R 33/482: {using a Cartesian trajectory} - G01R 33/4824: {using a non-Cartesian trajectory} - G01R 33/4835: {of multiple slices} - G01R 33/5611: {Parallel magnetic resonance imaging, e.g. sensitivity encoding [SENSE], simultaneous acquisition of spatial harmonics [SMASH], unaliasing by Fourier encoding of the overlaps using the temporal dimension [UNFOLD], k-t-broad-use linear acquisition speed-up technique [k-t-BLAST], k-t-SENSE (structural details of arrays of sub-coils G01R33/3415)} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract A dynamic contrast-enhanced MRI reconstruction method may include: when preparing to inject a contrast agent and during injection thereof, using a DCE-MRI sequence to scan an imaging target, and using a high temporal resolution scanning parameter value pre-inputted by a user to acquire K-space data of each phase with high temporal resolution; based on the acquired K-space data of each phase with high temporal resolution, reconstructing an image of each phase with high temporal resolution; based on a low temporal resolution reconstruction parameter value pre-inputted by the user, subjecting adjacent K-space data of multiple phases with high temporal resolution to summing and averaging in a complex field, and subjecting K-space data obtained after averaging to image reconstruction, to obtain an image of each phase with low temporal resolution. Advantageously, images with high and low temporal resolution can be obtained simultaneously with just a single DCE-MRI scan. ## Claims ### Claim 1 A dynamic contrast-enhanced magnetic resonance imaging reconstruction method, the method comprising: acquiring, using a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) sequence to scan an imaging target, and a received high temporal resolution scanning parameter value, K-space data of each phase with high temporal resolution in preparation of injection of a contrast agent and during injection thereof; reconstructing, based on the acquired K-space data of each phase with high temporal resolution, an image of each phase with high temporal resolution; and performing, based on a received low temporal resolution reconstruction parameter value and the high temporal resolution scanning parameter value used when acquiring K-space data of each phase with high temporal resolution: summing and averaging, in a complex field, of adjacent K-space data of multiple phases with high temporal resolution; and image reconstruction of K-space data obtained after averaging to obtain an image of each phase with low temporal resolution. ### Claim 2 (depends on 1) The method as claimed in claim 1, wherein the acquisition of the K-space data of each phase with high temporal resolution is based on: a preset K-space data filling method that includes a Cartesian filling, a radial filling, or spiral filling; and an acceleration method that includes a half-Fourier acquisition, a parallel acquisition, a multi-layer simultaneous acquisition, and/or compressed sensing sparse acquisition. ### Claim 3 (depends on 2) The method as claimed in claim 2, further comprising determining a reconstruction method according to the filling method and acceleration method used when acquiring K-space data of each phase with high temporal resolution, wherein: reconstructing the image of each phase with high temporal resolution is based on the determined reconstruction method; and the performing image reconstruction on the K-space data obtained after averaging is based on the determined reconstruction. ### Claim 4 (depends on 1) The method as claimed in claim 1, wherein summing and averaging, in the complex field, adjacent K-space data of multiple phases with high temporal resolution to summing and then averaging in a complex field is performed after phase correction and motion registration. ### Claim 5 (depends on 1) The method as claimed in claim 1, wherein the high temporal resolution scanning parameter value comprises: an acquisition time interval of two adjacent phases when acquiring K-space data with high temporal resolution, the acquisition time interval: remaining unchanged throughout acquisition of the K-space data with high temporal resolution, or increasing as a delay time after contrast agent injection increases throughout the acquisition of the K-space data with high temporal resolution. ### Claim 6 (depends on 1) The method as claimed in claim 1, wherein the low temporal resolution reconstruction parameter value comprises a time interval of two adjacent phases of a reconstructed low temporal resolution image, the time interval of two adjacent phases of the reconstructed low temporal resolution image: being constant in all reconstructed low temporal resolution phases, or increasing as a delay time after contrast agent injection increases. ### Claim 7 (depends on 1) The method as claimed in claim 1, wherein is high temporal resolution scanning parameter value is predetermined prior to acquisition of the K-space data. ### Claim 8 (depends on 1) The method as claimed in claim 1, wherein is high temporal resolution scanning parameter value is pre-inputted by a user. ### Claim 9 (depends on 1) A non-transitory computer-readable storage medium with an executable program stored thereon, that when executed, instructs a processor to perform the method of claim 1. ### Claim 10 A dynamic contrast-enhanced magnetic resonance imaging reconstruction apparatus, comprising: a K-space data acquisition module configured to, in preparation to inject a contrast agent and/or during injection thereof: scan an imaging target using a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) sequence to scan an imaging target, and acquire K-space data of each phase with high temporal resolution using a high temporal resolution scanning parameter value; a high temporal resolution image reconstruction module configured to reconstruct an image of each phase with high temporal resolution, based on the acquired K-space data of each phase with high temporal resolution; and a low temporal resolution image reconstruction module configured to: in a complex field, sum and then average adjacent K-space data of multiple phases with high temporal resolution, based on: a low temporal resolution reconstruction parameter value, and the high temporal resolution scanning parameter value used when acquiring K-space data of each phase with high temporal resolution; and perform image reconstruction to K-space data obtained after averaging to obtain an image of each phase with low temporal resolution. ### Claim 11 (depends on 10) The apparatus as claimed in claim 10, wherein, to acquire K-space data of each phase with high temporal resolution, the K-space data acquisition module is further configured to use: a preset K-space data filling method that includes a Cartesian filling, or a radial filling, or a spiral filling, and an acceleration method that includes a half-Fourier acquisition, a parallel acquisition, a multi-layer simultaneous acquisition, and/or a compressed sensing sparse acquisition. ### Claim 12 (depends on 11) The apparatus as claimed in claim 11, wherein: the reconstructing the image of each phase with high temporal resolution by the high temporal resolution image reconstruction module, comprises: determining a reconstruction method according to the filling method and acceleration method used when acquiring K-space data of each phase with high temporal resolution, and using the determined reconstruction method to reconstruct an image of each phase with high temporal resolution; and performing, by the low temporal resolution image reconstruction module, image reconstruction on the K-space data obtained after averaging comprises: determining a reconstruction method according to the filling method and acceleration method used when acquiring K-space data of each phase with high temporal resolution, and using the determined reconstruction method to subject K-space data obtained after averaging to image reconstruction. ### Claim 13 (depends on 10) The apparatus as claimed in claim 10, wherein the low temporal resolution image reconstruction module is configured to sum and average the adjacent K-space data of multiple phases with high temporal resolution after phase correction and motion registration. ### Claim 14 (depends on 10) The apparatus as claimed in claim 10, wherein the high temporal resolution scanning parameter value comprises: an acquisition time interval of two adjacent phases when acquiring K-space data with high temporal resolution, the acquisition time interval of two adjacent phases remaining unchanged throughout the period of acquiring K-space data with high temporal resolution or increasing as a delay time after contrast agent injection increases throughout acquisition of the K-space data with high temporal resolution. ### Claim 15 (depends on 10) The apparatus as claimed in claim 10, wherein the low temporal resolution reconstruction parameter value comprises a time interval of two adjacent phases of a reconstructed low temporal resolution image, the time interval of two adjacent phases of the reconstructed low temporal resolution image remaining constant in all reconstructed low temporal resolution phases or increasing as a delay time after contrast agent injection increases. ### Claim 16 (depends on 10) A magnetic resonance (MR) imaging system comprising: the dynamic contrast-enhanced magnetic resonance imaging reconstruction apparatus as claimed in claim 10. ### Claim 17 (depends on 16) The system as claimed in claim 16, further comprising a MR scanner. ### Claim 18 A dynamic contrast-enhanced magnetic resonance imaging reconstruction apparatus, comprising: one or more processors; and memory storing instructions that, when executed by the one or more processors, cause the apparatus to: acquire, using a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) sequence to scan an imaging target, and a received high temporal resolution scanning parameter value, K-space data of each phase with high temporal resolution in preparation of injection of a contrast agent and during injection thereof; reconstruct, based on the acquired K-space data of each phase with high temporal resolution, an image of each phase with high temporal resolution; and based on a received low temporal resolution reconstruction parameter value and the high temporal resolution scanning parameter value used when acquiring K-space data of each phase with high temporal resolution: sum and average, in a complex field, of adjacent K-space data of multiple phases with high temporal resolution; and perform image reconstruction of K-space data obtained after averaging to obtain an image of each phase with low temporal resolution.