Biomarkers of renal injury
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsKai Singbartl, John A. Kellum
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Abstract
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.
Claims23
A method for predicting long term dialysis dependence or dialysis independence, comprising:
- a) obtaining at least two urine samples derived from a patient within fourteen days of a renal injury;
- b) detecting hyaluronic acid values in the at least two urine samples with an immunoassay device;
- c) calculating a difference between the hyaluronic values of the at least two urine samples;
- d) combining at least one clinical indicia value with said hyaluronic acid difference value to create a patient value;
- and
- e) treating the patient with;
- i) long-term dialysis dependence when said patient value is above an area under the curve receiver operated characteristic (AUC ROC) hylauronic acid/clinical indicia threshold value;
- or ii) dialysis independence when said patient value is below an area under the AUC ROC hylauronic acid/clinical indicia threshold value.
Dependencies are inferred from the claim text.